To investigate whether the use of blood marker (plasma neutrophil gelatinase-associated lipocalin) can predict the development of subsequent kidney dysfunction in post non-heart surgical patients who are admitted to the intensive care unit

• Register: ANZCTR
• Last refreshed on: 13 January 2020
• Main ID: ACTRN12612000596808
• Date of registration: 01/06/2012
• Prospective Registration: Yes
• Primary sponsor: Shum Hoi Ping
• Public title: To investigate whether the use of blood marker (plasma neutrophil gelatinase-associated lipocalin) can predict the development of subsequent kidney dysfunction in post non-heart surgical patients who are admitted to the intensive care unit
• Scientific title: Does plasma neutrophil gelatinase-associated lipocalin predict acute kidney injury in post non-cardiac surgery-patients that require ICU care?
• Date of first enrolment: 01/12/2012
• Target sample size: 155
• Recruitment status: Completed
• URL: https://anzctr.org.au/ACTRN12612000596808.aspx
• Study type: Observational
• Study design: Purpose: Screening;Duration: Cross-sectional;Selection: Convenience sample;Timing: Prospective;
• Phase: Not Applicable

Countries of recruitment

Hong Kong

Contacts

• Name: Dr Dr Shum Hoi Ping

• Name: Dr Dr Shum Hoi Ping

Key inclusion & exclusion criteria

Inclusion criteria: 1. All emergency and elective post non-cardiac operation patients that required ICU care

2. Expected ICU length of stay >24 hours
Exclusion criteria: 1. Patients with chronic kidney disease stage 5 (Glomerular filtration rate estimated by Modification of Diet in Renal Disease (MDRD) equation of less than 15 ml/min) or those on renal replacement therapy
2. Surgical intervention that included nephrectomy
3. Cannot obtain consent from patients or their relatives

Age minimum: 18 Years
Age maximum: 85 Years
Gender: Both males and females

Health Condition(s) or Problem(s) studied

Acute kidney injury;Post non-cardiac operation;
Acute kidney injury
Post non-cardiac operation

Renal and Urogenital - Kidney disease

Surgery - Other surgery

Intervention(s)

The major objective of the study was to estimate the diagnostic accuracy of plasma NGAL on predicting subsequent development of acute kidney injury in non-cardiac postoperative patients that required intensive care. Plasma NGAL was taken within 1 hour and at 6th hour of post-operative ICU admission. Patients are observed until discharge from ICU to assess the presence of any acute kidney injury, requirement of renal support, ICU mortality

Primary Outcome(s)

Occurrence of Acute kidney injury, defined based on Risk, Injury, Failure, Loss and End stage (RIFLE) classification[48 hours from ICU admission]

Secondary Outcome(s)

Requirement of renal replacement therapy (needs of hemofiltration/ hemodiafiltration/ hemodialysis/ continuous renal replacement therapy, based on medical records upon ICU discharge)[During ICU stay]

ICU length of stay (based on medical records upon ICU discharge)[Upon ICU discharge]

ICU mortality (based on medical records upon ICU discharge)[Upon ICU discharge]

Secondary ID(s)

None

Source(s) of Monetary Support

Pamela Youde Nethersole Eastern Hospital

Secondary Sponsor(s)

SCIENCE INTERNATIONAL CORPORATION

Ethics review

Status: Approved
Approval date:
Contact:

Hong Kong East Cluster Ethics Committee