Perioperative ischaemic evaluation trial

• Register: ANZCTR
• Last refreshed on: 13 January 2020
• Main ID: ACTRN12605000308695
• Date of registration: 06/09/2005
• Prospective Registration: No
• Primary sponsor: MediClin Pty Ltd
• Public title: Perioperative ischaemic evaluation trial
• Scientific title: The effect of perioperative metoprolol on cardiac morbidity and mortality in patients presenting for non-cardiac surgery
• Date of first enrolment: 31/01/2003
• Target sample size: 10000
• Recruitment status: Completed
• URL: https://anzctr.org.au/ACTRN12605000308695.aspx
• Study type: Interventional
• Study design: Purpose: Prevention; Allocation: Randomised controlled trial; Masking: Blinded (masking used);Assignment: Parallel;Type of endpoint: Safety/efficacy;
• Phase: Phase 3 / Phase 4

Countries of recruitment

Australia

Contacts

• Name: Prof Associate Professor Kate Leslie

• Name: Prof Associate Professor Kate Leslie

Key inclusion & exclusion criteria

Inclusion criteria: With or at risk of ischaemic heart disease. Having moderatie or high risk non-cardiac surgery.
Exclusion criteria: Bradycardia or heart block, bronchospasm, recent CABG surgery, beta-blockers or verapamil.

Age minimum: 45 Years
Age maximum: Not stated
Gender: Both males and females

Health Condition(s) or Problem(s) studied

Surgery - Other surgery

Perioperative cardiac morbidity and mortality within 30 days of surgery;
Perioperative cardiac morbidity and mortality within 30 days of surgery

Intervention(s)

Metoprolol CR 200 mg daily for 30 days.

Primary Outcome(s)

Perioperative cardiac morbidity[30 days after surgery]

Perioperative cardiac mortality[30 days after surgery]

Secondary Outcome(s)

Safety outcomes[Within 30 days of surgery.]

Secondary ID(s)

Nil known

Source(s) of Monetary Support

AstraZeneca

NHMRC

CIHR

Ethics review

Status: Approved
Approval date:
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Alfred

Status: Not approved
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Auckland City

Status: Not approved
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Austin

Status: Not approved
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Box Hill

Status: Not approved
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Burnie

Status: Not approved
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Geelong Hospital

Status: Not approved
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John Hunter

Status: Not approved
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Kuala Lumpur

Status: Not approved
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Manukau

Status: Not approved
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Middlemore

Status: Not approved
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Penang

Status: Not approved
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Prince of Wales, Hong Kong

Status: Not approved
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Prince of Wales, Sydney

Status: Not approved
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Royal Melbourne

Status: Not approved
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Royal North Shore

Status: Not approved
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Royal Perth

Status: Not approved
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Royal Prince Alfred

Status: Not approved
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University Hospital Singapore

Status: Not approved
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Warringal Hospital

Status: Not approved
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Western

Status: Not approved
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Westmead