Comparison the effect of morphine and methadone on postoperative pain in opiate addicted patients undergoing CABG

• Register: TCTR
• Last refreshed on: 29 April 2024
• Main ID: TCTR20180109002
• Date of registration: 09/01/2018
• Prospective Registration: No
• Primary sponsor: shahid sadoughi university of medical sciences
• Public title: Comparison the effect of morphine and methadone on postoperative pain in opiate addicted patients undergoing CABG
• Scientific title: Comparison the effect of morphine and methadone on postoperative pain in opiate addicted patients undergoing CABG
• Date of first enrolment: 09/01/2016
• Recruitment status: Completed
• URL: https://www.thaiclinicaltrials.org/show/TCTR20180109002
• Study type: Interventional
• Study design: Randomized
• Phase: Phase 1/Phase 2

Countries of recruitment

Iran

Contacts

• Name: Hossein Moshtaghion
• Affiliation: Shahid Sadoughi university of medical sciences,Yazd, Iran

• Name: Hossein Moshtaghion
• Affiliation: Shahid Sadoughi university of medical sciences,Yazd, Iran

Key inclusion & exclusion criteria

Inclusion criteria: 76 opiate-addicted patients with ASA class II and III, aged < 90 years undergoing CABG
Exclusion criteria: history of preoperative renal failure requiring hemodialysis or serum creatinine greater than 2mg / dl, severe hepatic failure, EF less than 30%, pulmonary disease requiring oxygen therapy at home, a disease requiring the use of inotropes or intra-aortic pumps, emergency surgeries and allergy to methadone or intravenous morphine

Age minimum: 0 Years
Age maximum: 90 Years
Gender: Both

Health Condition(s) or Problem(s) studied

Ischemic heart disease (patients undergoing CABG)
postoperative pain, opiate-addicted patients, CABG

postoperative pain, opiate-addicted patients, CABG

Intervention(s)

Active Comparator Drug,Active Comparator Drug

0.15mg / kg of methadone ,0.1mg / kg of morphine

Primary Outcome(s)

mean pain scores At ICU admission 1 hour after ICU admission 2 hours after ICU admission 3 RASS and BPS score,nausia after the operation Questionnaire,vomiting after the operation Questionnaire

Secondary Outcome(s)

Hemodynamic variables ( MAP, O2SAT, HR) at the time of ICU admission, 1, 2, 3, and 4 hours after the operation, and 30 minutes and 2 hours a manomerty, pulse oxymetery, ECG

Source(s) of Monetary Support

shahid sadoughi university of medical sciences

Secondary Sponsor(s)

shahid sadoughi university of medical sciences,shahid sadoughi university of medical sciences

Ethics review

Status: Request not yet submitted
Approval date:
Contact:

Results

• Date Completed: 09/06/2017