The effect of nicardipine on the onset time and intubating conditions of cisatracurium

• Register: TCTR
• Last refreshed on: 29 April 2024
• Main ID: TCTR20170328002
• Date of registration: 28/03/2017
• Prospective Registration: No
• Primary sponsor: Faculty of Medicine, Prince of Songkhla University
• Public title: The effect of nicardipine on the onset time and intubating conditions of cisatracurium
• Scientific title: The effect of nicardipine on the onset time and intubating conditions of cisatracurium
• Date of first enrolment: 27/03/2017
• Target sample size: 99
• Recruitment status: Pending (Not yet recruiting)
• URL: https://www.thaiclinicaltrials.org/show/TCTR20170328002
• Study type: Interventional
• Study design: Randomized
• Phase: Phase 2

Countries of recruitment

Thailand

Contacts

• Name: Sahawat Thertchanakun
• Affiliation: Department of Anesthesiology, Faculty of Medicine, Prince of Songkhla University

• Name: Sahawat Thertchanakun
• Affiliation: Department of Anesthesiology, Faculty of Medicine, Prince of Songkhla University

Key inclusion & exclusion criteria

Inclusion criteria: - The patients receiving an elective surgery, which general anesthesia with endotracheal intubation is needed
- American Society of Anesthesiologists (ASA) Physical Status 1-2
- Normal Blood Pressure
Exclusion criteria: - The patients with Cardiac underlying diseases
- The patients with a history of Niicardipine or Cisatracurium allergy
- The pateints with a history of Malignant Hyperthemia
- The patients with a history of Neuromuscular disease
- The patients currently on cardiac pacemaker
- The pregnant patients
- The patients who are morbidly obese, defining as BMI of at least 35 kg per square meter
- The patients who are unable to communicate to give necessary information

Age minimum: 18 Years
Age maximum: 65 Years
Gender: Both

Health Condition(s) or Problem(s) studied

Intubation
Onset time of Cisatracurium
Nicardipine
Intubating condition
Grade of intubation
Hemodynamic response after intubation

Onset time of Cisatracurium
Nicardipine
Intubating condition
Grade of intubation
Hemodynamic response after intubation

Intervention(s)

Normal Saline 10 ml before induction agent,Nicardipine 10 mcg/kg + Normal Saline up to 10 ml,Nicardipine 20 mcg/kg + Normal Saline up to 10 ml

Placebo Comparator Drug,Experimental Drug,Experimental Drug

Normal Saline,Nicardipine 10 mcg/kg,Nicardipine 20 mcg/kg

Primary Outcome(s)

Effect of Nicardipine on Onset time of Cisatracurium After the Cisatracurium injection time, until maximal depression (TOF = 0) Duration since the Cisatracurium injection time to maximal depression (TOF = 0)

Secondary Outcome(s)

Grade of intubation After Intubation Intubation grade assessed by the intubating personnel,Intubating condition After intubation Intubating condition assessed by the intubating personnel,Hemodynamic response to intubation Every 1 minute until 5 minutes after intubation Blood Pressure, Heart Rate every 1 minute until 5 minutes after intubation

Source(s) of Monetary Support

Faculty of Medicine, Prince of Songkhla University

Secondary Sponsor(s)

Faculty of Medicine, Prince of Songkhla University

Ethics review

Status: Submitted, approved
Approval date:
Contact:

[e-mail]

Office of Human Research Ethics Committee (HREC), Faculty of Medicine, Prince of Songkhla University

074451149 Ext. 1157

[e-mail]

Results

• Date Completed: 30/09/2017