Accumbofrontal Tract Study in 2 Populations of Patients With Anorexia Nervosa and Obsessional Compulsive Disorder and Healthy Volunteer

• Register: ClinicalTrials.gov
• Last refreshed on: 19 April 2022
• Main ID: NCT03496285
• Date of registration: 05/04/2018
• Prospective Registration: Yes
• Primary sponsor: Poitiers University Hospital
• Public title: Accumbofrontal Tract Study in 2 Populations of Patients With Anorexia Nervosa and Obsessional Compulsive Disorder and Healthy Volunteer ACCUMBENS
• Scientific title: Multimodal MRI Study of Accumbofrontal Tract in Anorexia Nervosa and Obessional Compulsive Disorder : Search for Structural and Functional Changes Between Orbito-frontal Cortex and Accumbens Nucleus Subdivisions
• Date of first enrolment: May 9, 2018
• Target sample size: 30
• Recruitment status: Completed
• URL: https://clinicaltrials.gov/show/NCT03496285
• Study type: Interventional
• Study design: Allocation: N/A. Intervention model: Parallel Assignment. Primary purpose: Other. Masking: None (Open Label).
• Phase: N/A

Countries of recruitment

France

Key inclusion & exclusion criteria

Inclusion Criteria:

- Female patients

- Age between 18 and 65 years

- Subjects free to give their written consent

For anorexia nervosa :

- Patients meeting the diagnostic criteria for anorexia nervosa according to DSM5
(American Psychiatric Association): low weight (<85% of expected weight for age and
height), fear of gaining weight or becoming fat, distortion of body image, and
amenorrhea for more than 3 months

- Treatment with at least one antidepressant and one anxiolytic

For OCD :

- Patients meeting the diagnostic criteria of OCDs according to DSM5 (American
Psychiatric Association) : presence of obsessions and / or compulsions, resulting in
clinically significant suffering (loss of at least one hour per day) or impairment at
the social, occupational level or in another important area of life. These symptoms
are not due to the physiological effects of a substance or a general medical condition
and cannot be better explained by the symptoms of another psychiatric disorder.

- Patients with homogeneous OCD in obsession and compulsion.

- Normal weight compared to expected weight for age and height

- Treatment with at least one antidepressant and one anxiolytic

ForHealthy volunteer

•Normal weight compared to expected weight for age and height

Exclusion Criteria:

- Male

- Age <18 years or> 65 years

- Pregnancy

- Absence of free and informed consent signature

- Current processing by rTMS

- Somatic intercurrent pathologies: neurological, cardiological, pneumological, renal,
hepatic, endocrine, metabolic disorders ...

- Mental retardation (WAIS-IV QI <70)

- Primary Amenorrhea

- Absolute contraindication or relative to the realization of a magnetic resonance
imaging without injection of contrast medium

- Old or intercurrent psychotic pathology



Age minimum: 18 Years
Age maximum: 65 Years
Gender: Female

Health Condition(s) or Problem(s) studied

Accumbo Frontal Tract

Intervention(s)

Radiation: Multimodal MRI with diffusion sequence for anorexia nervosa patient

Radiation: Multimodal MRI with diffusion sequence for healthy volunteer

Radiation: Multimodal MRI with diffusion sequence for obsessional compulsive disorder patient

Primary Outcome(s)

Fractional Anisotropy (probabilistic tractography) [Time Frame: 20 minutes]

Secondary Outcome(s)

BOLD Signal (resting state) [Time Frame: 20 minutes]

Secondary ID(s)

ACCUMBENS

Source(s) of Monetary Support

Please refer to primary and secondary sponsors