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Main
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Note: This record shows only 22 elements of the WHO Trial Registration Data Set. To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register. |
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Register:
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ClinicalTrials.gov |
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Last refreshed on:
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16 December 2017 |
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Main ID: |
NCT03352986 |
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Date of registration:
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10/10/2017 |
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Prospective Registration:
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No |
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Primary sponsor: |
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Public title:
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Substudy of CADRE: for People With Extreme Phenotype: BIOCADRE
BIOCADRE |
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Scientific title:
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A Substudy of the CADRE Study: Determination of Clinical Markers in Patients With Extreme Sickle Cell Disease Phenotype |
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Date of first enrolment:
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May 15, 2017 |
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Target sample size:
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300 |
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Recruitment status: |
Recruiting |
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URL:
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https://clinicaltrials.gov/show/NCT03352986 |
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Study type:
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Observational |
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Study design:
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Phase:
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N/A
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Countries of recruitment
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Mali
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Senegal
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Contacts
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Name:
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Brigitte Ranque, MD |
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Address:
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Telephone:
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0156092772 |
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Email:
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brigitte.ranque@aphp.fr |
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Affiliation:
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Name:
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Brigitte Ranque, MD |
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Address:
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Telephone:
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Email:
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Affiliation:
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Institut National de la Santé Et de la Recherche Médicale, France |
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Key inclusion & exclusion criteria
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Inclusion Criteria:
- sickle cell patients with extreme phenotypes: SS-hemoglobin
Exclusion Criteria:
- transfusion in the previous 2 months
- vaso-occlusive crisis in the previous 15 days
- infection in the previous 8 days
Age minimum:
10 Years
Age maximum:
N/A
Gender:
All
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Health Condition(s) or Problem(s) studied
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Sickle Cell Disease
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Intervention(s)
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Other: peripheral arterial tonometry
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Biological: biological analysis
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Primary Outcome(s)
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Description of microcirculation by peripheral arterial tonometry
[Time Frame: 1 year]
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Secondary Outcome(s)
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Measurement of neutrophil extracellular trap (NET)
[Time Frame: 1 year]
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Measurement of proinflammatory cytokines by ELISA
[Time Frame: 1 year]
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Genotyping of the polymorphisms associated with persistence of fetal hemoglobin
[Time Frame: 1 year]
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Dosage of microparticles
[Time Frame: 1 year]
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Measure of blood viscosities
[Time Frame: 1 year]
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Determination of free hemoglobin
[Time Frame: 1 year]
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Genotyping of the alpha-globin gene associated with persistence of fetal hemoglobin
[Time Frame: 1 year]
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Source(s) of Monetary Support
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Please refer to primary and secondary sponsors
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Results
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Results available:
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Date Posted:
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Date Completed:
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URL:
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