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Main
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Note: This record shows only 22 elements of the WHO Trial Registration Data Set. To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register. |
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Register:
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ClinicalTrials.gov |
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Last refreshed on:
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16 December 2017 |
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Main ID: |
NCT03276598 |
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Date of registration:
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06/09/2017 |
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Prospective Registration:
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No |
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Primary sponsor: |
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Public title:
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A Study on Molecular Genetics of Drug Responsiveness in Essential Hypertension
GENRES |
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Scientific title:
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A Randomised Double-blind Cross-over Single-centre Study on Molecular Genetics of Drug Responsiveness in Essential Hypertension |
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Date of first enrolment:
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November 25, 1999 |
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Target sample size:
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233 |
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Recruitment status: |
Completed |
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URL:
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https://clinicaltrials.gov/show/NCT03276598 |
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Study type:
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Interventional |
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Study design:
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Allocation: Randomized. Intervention model: Crossover Assignment. Primary purpose: Treatment. Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor).
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Phase:
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Phase 4
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Countries of recruitment
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Finland
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Contacts
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Name:
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Kimmo K Kontula, Professor |
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Address:
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Telephone:
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Email:
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Affiliation:
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Helsinki University Central Hospital |
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Key inclusion & exclusion criteria
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Inclusion Criteria:
- essential hypertension diagnosed on an earlier occasion or during the present study
(three diastolic blood pressure readings >=95 mmHg on separate occasions are
required).
Exclusion Criteria (before and during the study):
- usage of three or more antihypertensive drugs
- secondary hypertension
- left ventricular hypertrophy
- drug-treated diabetes mellitus
- coronary heart disease
- stroke and other disorders of cerebral circulation
- renal disease
- obstructive pulmonary disease
- a disease treated with corticosteroids
- a disease with drug treatment potentially influencing blood pressure levels
- significant obesity (BMI >=32 kg/m2)
- allergic reaction towards any of the study drugs
- The patient is excluded from the study if his blood pressure level rises to 200/120
mmHg or above during the study.
Age minimum:
35 Years
Age maximum:
59 Years
Gender:
Male
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Health Condition(s) or Problem(s) studied
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Hypertension
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Pharmacogenetics
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Intervention(s)
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Drug: Placebo
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Drug: Amlodipine
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Drug: Losartan
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Drug: Hydrochlorothiazide
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Drug: Bisoprolol
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Primary Outcome(s)
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Blood pressure
[Time Frame: 4 weeks]
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Source(s) of Monetary Support
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Please refer to primary and secondary sponsors
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Results
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Results available:
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Date Posted:
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Date Completed:
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URL:
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