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Main
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Note: This record shows only 22 elements of the WHO Trial Registration Data Set. To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register. |
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Register:
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ClinicalTrials.gov |
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Last refreshed on:
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19 April 2022 |
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Main ID: |
NCT03211000 |
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Date of registration:
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05/07/2017 |
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Prospective Registration:
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No |
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Primary sponsor: |
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Public title:
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Autophagy, Oxidative Stress and Hippo Signaling in Human Aortic Aneurysm
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Scientific title:
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Study of the Molecular Mechanisms Associated With the Formation of Human Aortic Aneurysm: a Focus on Autophagy, Oxidative Stress and Hippo Signaling |
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Date of first enrolment:
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June 1, 2017 |
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Target sample size:
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30 |
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Recruitment status: |
Completed |
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URL:
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https://clinicaltrials.gov/show/NCT03211000 |
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Study type:
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Observational |
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Study design:
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Phase:
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Countries of recruitment
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Italy
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Contacts
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Name:
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Giacomo Frati, MD |
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Address:
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Telephone:
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Email:
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Affiliation:
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IRCCS Neuromed |
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Key inclusion & exclusion criteria
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Inclusion Criteria:
- Eligible subjects undergoing aortic surgical procedures
- Ejection fraction (FE) > 30%
- Acceptance and signature of the informed consent
Exclusion Criteria:
- Acute myocardial infarction in the last 6 months
- Chronic and acute Inflammatory diseases
- Immunological and rheumatic diseases
- Pre-existing or ongoing neoplasms
- infectious diseases
- Treatment with pharmacological therapies able to modulate autophagy, i. e. rapamycin
and derivative compounds (rapalogues))
- Antioxidant therapies in the last three months
- Patients with surgical technical complications
Age minimum:
18 Years
Age maximum:
85 Years
Gender:
All
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Health Condition(s) or Problem(s) studied
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Aortic Aneurysm
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Primary Outcome(s)
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Comparison between the levels of Hippo signaling and autophagy markers observed in aortic aneurysms and the levels assessed in the adjacent non-aneurysmatic aortic portions.
[Time Frame: 1 month]
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Secondary Outcome(s)
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Impact of cardiovascular risk factors on the autophagy levels in aortic samples of patients undergoing surgical procedure of aortic aneurysm removal.
[Time Frame: 1 month]
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Correlation between levels of autophagy and endothelial function in patients undergoing surgical procedure of aortic aneurysm removal
[Time Frame: 1 month]
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Correlation between levels of autophagy and the size of aortic aneurysms
[Time Frame: 1 month]
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Correlation between levels of autophagy and apoptosis in aneurysmal samples
[Time Frame: 1 month]
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Source(s) of Monetary Support
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Please refer to primary and secondary sponsors
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Results
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Results available:
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Date Posted:
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Date Completed:
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URL:
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