Epileptiform EEG Patterns During Induction of General Anaesthesia With Sevoflurane Compared to Those With Propofol

• Register: ClinicalTrials.gov
• Last refreshed on: 16 December 2017
• Main ID: NCT03209323
• Date of registration: 02/07/2017
• Prospective Registration: No
• Primary sponsor: Medical University of Silesia
• Public title: Epileptiform EEG Patterns During Induction of General Anaesthesia With Sevoflurane Compared to Those With Propofol EEG
• Scientific title: Influence of Volatile Induction of General Anaesthesia With Sevoflurane Using Two Different Techniques and Intravenous Induction Using Propofol on the Epileptiform Electroencephalograph Patterns:
• Date of first enrolment: January 1, 2007
• Target sample size: 60
• Recruitment status: Completed
• URL: https://clinicaltrials.gov/show/NCT03209323
• Study type: Interventional
• Study design: Allocation: Randomized. Intervention model: Parallel Assignment. Primary purpose: Diagnostic. Masking: Single (Participant).
• Phase: N/A

Countries of recruitment

Poland

Contacts

• Name: Przemyslaw Jalowiecki
• Affiliation: Silesian University of Medicine

Key inclusion & exclusion criteria

Inclusion Criteria:

- an American Society of Anaesthesiologists (ASA) score I-II

- written informed consent to undergo general anaesthesia

Exclusion Criteria:

- history of epilepsy, medical treatment that might interfere with the EEG (e.g.,
tranquilizers, antiepileptic drugs), pregnancy, drug or alcohol abuse, history of
neurological disease or a neurosurgical operation that would impair EEG or BIS monitoring,
history of pulmonary disease, or the presence of signs predicting difficult mask
ventilation or intubation. any pre-existing epileptic EEG patterns in standard 30-minute
initial EEG recordings performed in all the patients participating in the study.



Age minimum: 18 Years
Age maximum: 70 Years
Gender: All

Health Condition(s) or Problem(s) studied

Electroencephalography

Depth of Anaesthesia

General Anaesthesia

Intraoperative Awareness

Seizures

Intervention(s)

Device: bispectral index (BIS)

Device: response and state entropy (RE and SE)

Device: middle latency auditory evoked potentials (MLAEP)

Device: electroencephalography (EEG)

Primary Outcome(s)

presence of epileptiform patterns in patients EEGs [Time Frame: intraoperative]

Secondary Outcome(s)

observance of BIS score behaviour during presence of epileptiform patterns in patients EEGs [Time Frame: intraoperative]

observance of values of middle latency auditory evoked potentials behaviour during presence of epileptiform patterns in patients [Time Frame: intraoperative]

observance of values of state and response entropy behaviour during presence of epileptiform patterns in patients [Time Frame: intraoperative]

Secondary ID(s)

SilesianMUKOAIIT6

Source(s) of Monetary Support

Please refer to primary and secondary sponsors

Secondary Sponsor(s)

Silesian University of Medicine