Efficacy of Low Dose of Proton Pump Inhibitor in Treatment Bleeding Ulcers

• Register: ClinicalTrials.gov
• Last refreshed on: 12 December 2020
• Main ID: NCT03163680
• Date of registration: 15/05/2017
• Prospective Registration: No
• Primary sponsor: Damascus Hospital
• Public title: Efficacy of Low Dose of Proton Pump Inhibitor in Treatment Bleeding Ulcers
• Scientific title: Efficacy of Low Dose of Proton Pumb Inhabitor in Treatment Upper Gastrointestinal Bleeding
• Date of first enrolment: January 2012
• Target sample size: 295
• Recruitment status: Completed
• URL: https://clinicaltrials.gov/show/NCT03163680
• Study type: Observational

Countries of recruitment

Syrian Arab Republic

Key inclusion & exclusion criteria

Criteria:

Inclusion Criteria:

High risk ulcers defined according to the Forrest classification With respect to high-risk
stigmata, active bleeding was defined as a continuous blood spurting (Forrest IA) oozing
(Forrest IB) from the ulcer base. A non-bleeding visible vessel at endoscopy was defined as
a discrete protuberance at the ulcer base(Forrest IIA).

An adherent clot was one that was resistant to forceful irrigation or suction (Forrest
IIB).

Exclusion Criteria:

ulcer was malignant non ulcerative bleeding such as angiodysplasia , a Mallory-Weiss tear



Age minimum: 18 Years
Age maximum: 90 Years
Gender: All

Health Condition(s) or Problem(s) studied

Marginal Ulcer

Gastroduodenal Ulcer

Peptic Ulcer Hemorrhage

Intervention(s)

Drug: Omeprazole 40 MG

Primary Outcome(s)

Morality [Time Frame: within 1 week]

Secondary Outcome(s)

Blood transfusions [Time Frame: within 1 week]

Length of hospital stay [Time Frame: within 1 month]

need for surgery [Time Frame: within 1 week]

Rebleeding [Time Frame: within 1 week]

Secondary ID(s)

G6-17

Source(s) of Monetary Support

Please refer to primary and secondary sponsors