Medical and Physiological Benefits of Reduced Sitting

• Register: ClinicalTrials.gov
• Last refreshed on: 12 December 2020
• Main ID: NCT03101228
• Date of registration: 24/03/2017
• Prospective Registration: Yes
• Primary sponsor: Turku University Hospital
• Public title: Medical and Physiological Benefits of Reduced Sitting
• Scientific title: Medical and Physiological Benefits and Mechanisms of Reduced Sitting Without Meeting the Current Physical Activity Recommendations
• Date of first enrolment: April 25, 2017
• Target sample size: 64
• Recruitment status: Completed
• URL: https://clinicaltrials.gov/show/NCT03101228
• Study type: Interventional
• Study design: Allocation: Randomized. Intervention model: Parallel Assignment. Primary purpose: Prevention. Masking: Single (Outcomes Assessor).
• Phase: N/A

Countries of recruitment

Finland

Contacts

• Name: Juhani Knuuti, Professor
• Affiliation: Turku PET Centre, Turku University Hospital

Key inclusion & exclusion criteria

Inclusion Criteria:

- Physically inactive (less than 120 minutes of moderate intensity exercise per week
measured by the activity monitor during run-in)

- Sitting time = 10 h /day (measured by the activity monitor during run-in)

- BMI 25-40

- Blood pressure < 160/100 mmHg

- Fasting plasma glucose < 7.0 mmol/l

- Fulfills the criteria of the metabolic syndrome according to Alberti et al 2009

Exclusion Criteria:

- History of a cardiac event

- Insulin or medically treated diabetes

- Any chronic disease or condition that could create a hazard to the subject safety,
endanger the study procedures or interfere with the interpretation of study results

- Presence of ferromagnetic objects that would make MR imaging contraindicated

- Abundant use of alcohol

- Use of narcotics

- Smoking of tobacco or consuming snuff tobacco

- Diagnosed depressive or bipolar disorder

- Previous PET imaging or considerable exposure to radiation



Age minimum: 40 Years
Age maximum: 65 Years
Gender: All

Health Condition(s) or Problem(s) studied

Physical Activity

Metabolic Syndrome

Cardiovascular Diseases

Insulin Resistance

Intervention(s)

Behavioral: Reduced sitting

Primary Outcome(s)

The change in skeletal muscle insulin-stimulated glucose uptake [Time Frame: The change from baseline to 6 months]

The change in whole-body insulin sensitivity [Time Frame: The change from baseline to 6 months]

Secondary Outcome(s)

daily hours spent physically active [Time Frame: through study completion, an average of 6 months]

The change in maximal oxygen uptake [Time Frame: The change from baseline to 6 months]

The change in body fat percentage [Time Frame: The change from baseline to 6 months]

The change in plasma glucose [Time Frame: The change from baseline to 3 months]

daily sitting hours [Time Frame: through study completion, an average of 6 months]

The change in plasma glucose [Time Frame: The change from baseline to 6 months]

The change in liver adiposity [Time Frame: The change from baseline to 6 months]

The change in body fat percentage [Time Frame: The change from baseline to 3 months]

The change in HbA1c [Time Frame: The change from baseline to 3 months]

The change in HbA1c [Time Frame: The change from baseline to 6 months]

Secondary ID(s)

T91/2017

Source(s) of Monetary Support

Please refer to primary and secondary sponsors

Secondary Sponsor(s)

UKK Institute