Low Intensity Resistance Training With Vascular Occlusion in Coronary Heart Disease Patients

• Register: ClinicalTrials.gov
• Last refreshed on: 16 December 2017
• Main ID: NCT03087292
• Date of registration: 15/03/2017
• Prospective Registration: No
• Primary sponsor: University Medical Centre Ljubljana
• Public title: Low Intensity Resistance Training With Vascular Occlusion in Coronary Heart Disease Patients
• Scientific title: Effect of Low Intensity Resistance Training With Vascular Occlusion on Muscle Hypertrophy, Neuromuscular Adaptations and Selected Cardiovascular Parameters in Patients With Coronary Heart Disease
• Date of first enrolment: February 27, 2017
• Target sample size: 30
• Recruitment status: Recruiting
• URL: https://clinicaltrials.gov/show/NCT03087292
• Study type: Interventional
• Study design: Allocation: Randomized. Intervention model: Parallel Assignment. Primary purpose: Treatment. Masking: None (Open Label).
• Phase: N/A

Countries of recruitment

Slovenia

Contacts

• Name: Borut Jug, PhD, MD

• Name: Tim Kambic, BSc

Key inclusion & exclusion criteria

Inclusion Criteria:

- above 18 years old and below 75 years old

- coronary heart disease documented with clinical event

- stable coronary heart disease patients

Exclusion Criteria:

- Unstable phase of coronary heart disease

- dysfunction of left ventricle

- residual myocardial ischemia

- contraindications for physical activity,

- intellectual development disorder,

- recent dissection of aorta

- recent vein thrombolysis



Age minimum: 18 Years
Age maximum: 75 Years
Gender: All

Health Condition(s) or Problem(s) studied

Coronary Artery Disease

Coronary Disease

Intervention(s)

Other: Resistance training with vascular occlusion

Primary Outcome(s)

Change in maximal strength [Time Frame: 4 weeks, 8 weeks]

Secondary Outcome(s)

Change of the value of norepinephrine [Time Frame: 4 and 8 weeks]

Change of the value of blood human growth hormon (HGH) [Time Frame: 4 and 8 weeks]

Change in heat-shock protein (HSP-72) [Time Frame: 4 and 8 weeks]

Change in resting and post-exercise heart rate [Time Frame: 4 and 8 weeks]

Change in maximal voluntary contraction (MVC) [Time Frame: 4 and 8 weeks]

Change of the value of testosterone [Time Frame: 4 and 8 weeks]

Change in blood pressure prior and after exercise [Time Frame: 1-8 week]

Change in C-reactive protein [Time Frame: 4 and 8 weeks]

Change of from-the-questionnaire-obtained quality of life [Time Frame: 4 and 8 weeks]

Change of the value of insulin-like growth factor (IGF-1) [Time Frame: 4 and 8 weeks]

Change of the value of cortisol [Time Frame: 4 and 8 weeks]

Change in muscle hypertrophy (muscle thickness) [Time Frame: 4 and 8 weeks]

Change of the value of epinephrine [Time Frame: 4 and 8 weeks]

Change of the value of mechano growth factor (MGF) [Time Frame: 4 and 8 weeks]

Change of the value of myostatin [Time Frame: 4 and 8 weeks]

Changes of flow-mediated dilatation of the brachial artery [Time Frame: 4 weeks, 8 weeks]

Secondary ID(s)

UKCLRehab022017

Source(s) of Monetary Support

Please refer to primary and secondary sponsors

Secondary Sponsor(s)

University of Ljubljana, Faculty of Sport