Carbon Monoxide Migraine-inducing Effects in Patients With Migraine Without Aura.

• Register: ClinicalTrials.gov
• Last refreshed on: 8 January 2018
• Main ID: NCT03075020
• Date of registration: 06/03/2017
• Prospective Registration: No
• Primary sponsor: Danish Headache Center
• Public title: Carbon Monoxide Migraine-inducing Effects in Patients With Migraine Without Aura.
• Scientific title: Basic Research on Carbon Monoxide's Headache Inducing Characteristics in a Humane Experimental Headache Model
• Date of first enrolment: October 2016
• Target sample size: 12
• Recruitment status: Completed
• URL: https://clinicaltrials.gov/show/NCT03075020
• Study type: Interventional
• Study design: Allocation: Randomized. Intervention model: Crossover Assignment. Primary purpose: Basic Science. Masking: Double (Participant, Investigator).
• Phase: N/A

Countries of recruitment

Denmark

Key inclusion & exclusion criteria

Inclusion Criteria:

- Healthy volunteers

- Aged 18-50

- 50-100 kg

Exclusion Criteria:

- Tension type headache more than once/month

- Other primary headaches

- Daily medication except contraceptives

- Drug taken within 4 times the halflife for the specific drug except contraceptives

- Pregnant or lactating women

- Exposure to radiation within the last year

- Headache within the last 24 hours before start of trial

- Hypertension

- Hypotension

- Respiratory or cardiac disease

- Smoking

- Primary relatives with current or previous migraine



Age minimum: 18 Years
Age maximum: 50 Years
Gender: All

Health Condition(s) or Problem(s) studied

Headache, Migraine

Intervention(s)

Other: Carbon monoxide

Other: AIR

Primary Outcome(s)

Headache scores, 12 hours [Time Frame: 12 hours]

Secondary Outcome(s)

Facial blood flow [Time Frame: [ Time Frame: 0-180 min ]]

Secondary ID(s)

H-16021497

Source(s) of Monetary Support

Please refer to primary and secondary sponsors