Genetic Variation in Gonadotropin and Gonadotropin Receptor Genes and Suboptimal Response

• Register: ClinicalTrials.gov
• Last refreshed on: 12 December 2020
• Main ID: NCT03007043
• Date of registration: 28/12/2016
• Prospective Registration: No
• Primary sponsor: Institut Universitari Dexeus
• Public title: Genetic Variation in Gonadotropin and Gonadotropin Receptor Genes and Suboptimal Response
• Scientific title: Genetic Variation in Gonadotropin and Gonadotropin Receptor Genes as a Causative Factor of Suboptimal Response Following Ovarian Stimulation for IVF/ICSI. A Prospective Cohort Study
• Date of first enrolment: November 2016
• Target sample size: 364
• Recruitment status: Completed
• URL: https://clinicaltrials.gov/show/NCT03007043
• Study type: Observational

Countries of recruitment

Spain, Vietnam

Key inclusion & exclusion criteria

Inclusion Criteria:

1. Age between 18-38 years old

2. BMI 18-28

3. Antral follicle count (AFC) > 9 or Anti-mullerian hormone (AMH) >1.1 ng/ml

4. 1st or 2nd ovarian stimulation cycle for IVF/ICSI

5. Planned to undergo ovarian stimulation with 150IU of rFSH in a fixed GnRH antagonist
protocol

Exclusion Criteria:

1. Antral follicle count (AFC) <9 and AMH<1.1 ng/ml

2. PCOS patients according to the Rotterdam criteria

3. Patients undergoing in vitro maturation (IVM)

4. Untreated endocrine abnormalities



Age minimum: 18 Years
Age maximum: 38 Years
Gender: Female

Health Condition(s) or Problem(s) studied

Fertility Disorders

Intervention(s)

Other: blood sample

Primary Outcome(s)

prevalence of the main FSH receptor polymorphism [Time Frame: 12 months]

Secondary ID(s)

2016.Polymorphisms_COS

Source(s) of Monetary Support

Please refer to primary and secondary sponsors