Alzheimer's Disease and Physiological, Cognitive Function and BDNF Levels of Plasma Adaptation After Exercise Training

• Register: ClinicalTrials.gov
• Last refreshed on: 12 December 2020
• Main ID: NCT02968875
• Date of registration: 07/09/2016
• Prospective Registration: No
• Primary sponsor: University Hospital Center of Martinique
• Public title: Alzheimer's Disease and Physiological, Cognitive Function and BDNF Levels of Plasma Adaptation After Exercise Training MARAE
• Scientific title: Alzheimer's Disease and Physiological, Cognitive Function and BDNF Levels of Plasma Adaptation After Exercise Training
• Date of first enrolment: July 2015
• Target sample size: 54
• Recruitment status: Completed
• URL: https://clinicaltrials.gov/show/NCT02968875
• Study type: Interventional
• Study design: Allocation: Randomized. Intervention model: Parallel Assignment. Primary purpose: Prevention. Masking: None (Open Label).
• Phase: N/A

Countries of recruitment

France, Martinique

Contacts

• Name: Jean-Luc Ms FANON, Doctor
• Affiliation: CHU de Martinique

Key inclusion & exclusion criteria

Inclusion Criteria:

- Alzheimer's disease patients diagnosed by a consultation memory (DSM- IV)

- Person with at least 60 years

- Person with a score higher than 15 in the Mini Mental State Examination

- No one can achieve the pedaling motion

- People who do not perform regular physical activity on bike

- Nobody has given free and informed consent in writing or obtained from a trusted
person or the family environment

- People affiliated to a social security

Exclusion Criteria:

- Patient who refused to provide written consent

- Inability to pedal

- Recent myocardial necrosis (less than 3 months)

- Aortic Stenosis

- Uncompensated heart failure

- Unstable angina

- Ventricular arrythmia

- Pulmonary embolism

- Coxarthrosis, knee, ankle osteoarthritis

- Not affiliated to a social security

- Patient already participating in another biomedical research



Age minimum: 18 Years
Age maximum: 60 Years
Gender: All

Health Condition(s) or Problem(s) studied

Alzheimer's Disease

Intervention(s)

Device: Endurance Training

Other: therapeutic education meetings

Primary Outcome(s)

Measuring the effect of a program of endurance training (ET), on the levels of plasma BDNF. [Time Frame: Up to 4 months]

Secondary Outcome(s)

Measuring the effect of training on the physiological performance with a walk test of 6 minutes. [Time Frame: Up to 4 months]

Measuring the effect of training on the psychological performance by using questionnaire: quality of life (QoL-AD) [Time Frame: Up to 4 months]

Measuring the effect of training on the psychological performance by using questionnaire MMSE [Time Frame: Up to 4 months]

Measuring the effect of training on the psychological performance by using questionnaire: Rey auditory verbal learning test (RAVLT) [Time Frame: Up to 4 months]

Stress test [Time Frame: Up to 4 months]

Secondary ID(s)

15/B/03

Source(s) of Monetary Support

Please refer to primary and secondary sponsors