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Main
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Note: This record shows only 22 elements of the WHO Trial Registration Data Set. To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register. |
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Register:
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ClinicalTrials.gov |
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Last refreshed on:
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5 September 2016 |
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Main ID: |
NCT02872818 |
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Date of registration:
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16/08/2016 |
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Prospective Registration:
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No |
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Primary sponsor: |
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Public title:
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Apoptotic Signaling Pathways in Rats With Endometrial Hyperplasia
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Scientific title:
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The Effect of Metformin and Medroxyprogesterone Acetate on Apoptotic Signaling Pathways in Wistar-Albino Rats With Induced Endometrial Hyperplasia |
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Date of first enrolment:
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October 2014 |
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Target sample size:
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40 |
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Recruitment status: |
Completed |
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URL:
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https://clinicaltrials.gov/show/NCT02872818 |
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Study type:
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Interventional |
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Study design:
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Outcomes Assessor), Primary Purpose: Treatment
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Phase:
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Phase 4
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Countries of recruitment
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Turkey
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Contacts
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Name:
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Erdem SAHIN |
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Address:
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Telephone:
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Email:
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Affiliation:
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Kayseri Training and Research Hospital |
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Key inclusion & exclusion criteria
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Inclusion criteria:
Forty-eight weeks old female Wistar-Albino rats, weighting between 180 and 260 g
Exclusion criteria.
We have no exclusion criteria because we examine drugs effects in the experimental rats
Age minimum:
8 Weeks
Age maximum:
10 Weeks
Gender:
Female
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Health Condition(s) or Problem(s) studied
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Apoptotic Signal Pathways in Endometrial Hyperplasia
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Intervention(s)
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Drug: 17ß estradiol hemihydrate
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Drug: medroxyprogesterone acetate
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Drug: Metformin
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Primary Outcome(s)
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Bax Gene Expression Levels in Rat Uterine Tissue
[Time Frame: 4 months]
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Bcl-2 Gene Expression Levels in Rat Uterine Tissue
[Time Frame: 4 months]
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c-Myc Gene Expression Levels in Rat Uterine Tissue
[Time Frame: 4 months]
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Caspase-9 Expression Levels in Rat Uterine Tissue
[Time Frame: 4 months]
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Survivin Gene Expression Levels in Rat Uterine Tissue
[Time Frame: 4 months]
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Source(s) of Monetary Support
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Please refer to primary and secondary sponsors
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Results
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Results available:
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Date Posted:
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Date Completed:
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URL:
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