Molecular Response After Concurrent Exercise With Low Glycogen

• Register: ClinicalTrials.gov
• Last refreshed on: 12 December 2020
• Main ID: NCT02668445
• Date of registration: 26/01/2016
• Prospective Registration: No
• Primary sponsor: Wageningen University
• Public title: Molecular Response After Concurrent Exercise With Low Glycogen Glyconcurrent
• Scientific title: The Effects of Glycogen Availability on the Skeletal Muscle Molecular Response After Concurrent Exercise
• Date of first enrolment: November 2015
• Target sample size: 14
• Recruitment status: Completed
• URL: https://clinicaltrials.gov/show/NCT02668445
• Study type: Interventional
• Study design: Allocation: Randomized. Intervention model: Crossover Assignment. Primary purpose: Treatment. Masking: None (Open Label).
• Phase: N/A

Countries of recruitment

Netherlands

Key inclusion & exclusion criteria

Inclusion Criteria:

- Male gender between 18 and 30 years of age

- BMI between 18.5 - 25 kg/m2

- Participating in regular exercise training (at least 1 exercise session, and a maximum
of 3 exercise session per week)

- Used to different types of exercise (endurance, resistance and/or concurrent)

- Willing to give blood samples

- Willing to give muscle biopsies

- No use of antibiotics during the study or in the past month

- No drug use

- Suitable veins for blood withdrawal

- Registered by a general-practitioner

- Consumption of alcohol beverages is less than 21 per week

- No blood donor during the study

- No vegetarian and willing to eat meat during the experimental days

- Able to be present and participate at both test days and pre testing moments

- Not employed, or intern, or working on thesis at the department of Human Nutrition at
Wageningen University

- Not participating in another scientific study (except EetMeetWeet)

- Able to participate during the experimental days en pre tests

- Able to speak Dutch

Exclusion Criteria:

- Medical condition that can interfere with the study outcome (i.e. cardiovascular
disease, pulmonary disease, gluten intolerance)

- Systolic blood pressure >160 mmHg and/or diastolic blood pressure >100 mmHg

- Use of medications known to interfere with gene expression in the muscles (i.e.
statins, fenofibrate)

- Use of antithrombotic therapy (marcoumar, sintromitis).

- Diagnosed diabetes mellitus type 1 or 2

- (Chronic) injuries of the locomotor system that can interfere with the intervention



Age minimum: 18 Years
Age maximum: 30 Years
Gender: Male

Health Condition(s) or Problem(s) studied

Healthy

Intervention(s)

Other: Standard meal containing low or high carbohydrate content

Primary Outcome(s)

Proteins involved in hypertrophy [Time Frame: 10 hours]

Secondary ID(s)

NL54408.081.15

Source(s) of Monetary Support

Please refer to primary and secondary sponsors