Endometrial Injury and Implantation Rates Before First ICSI Cycle

• Register: ClinicalTrials.gov
• Last refreshed on: 12 February 2024
• Main ID: NCT02660125
• Date of registration: 17/01/2016
• Prospective Registration: No
• Primary sponsor: Cairo University
• Public title: Endometrial Injury and Implantation Rates Before First ICSI Cycle
• Scientific title: Does Local Endometrial Injury Improve Implantation Rates in Women Undergoing Their First ICSI Cycle.
• Date of first enrolment: January 2016
• Target sample size: 300
• Recruitment status: Completed
• URL: https://clinicaltrials.gov/ct2/show/NCT02660125
• Study type: Interventional
• Study design: Allocation: Randomized. Intervention model: Single Group Assignment. Primary purpose: Treatment. Masking: Double (Investigator, Outcomes Assessor).
• Phase: N/A

Countries of recruitment

Egypt

Contacts

• Name: Ahmed Maged
• Affiliation: Kasr Alainy medical school

Key inclusion & exclusion criteria

Inclusion Criteria:

1. subfertile women indicated for ICSI.

2. normal uterine cavity demonstrated by transvaginal ultrasound and hystrogram.

3. FSH<10mIU/mL on day 3 of her cycle.

Exclusion Criteria:

1. presence of endometrial polyp or fibroid distorting the uterine cavity.

2. hydrosalpinx.

3. ICSI carried out for preimplantation genetic diagnosis.

4. FSH>10mIU\mL.



Age minimum: 20 Years
Age maximum: 40 Years
Gender: Female

Health Condition(s) or Problem(s) studied

Invitro Fertilization

Intervention(s)

Procedure: Endometrial scratch injury

Primary Outcome(s)

clinical pregnancy rate [Time Frame: 4 weeks after embryo transfer]

implantation rate [Time Frame: 14 days after embryo transfer]

Secondary Outcome(s)

multiple pregnancy rate [Time Frame: 4 weeks after embryo transfer]

abortion rate [Time Frame: 12 weeks of gestational age]

Secondary ID(s)

144

Source(s) of Monetary Support

Please refer to primary and secondary sponsors