Induction of Neutrophilic Traps ( NETs ) by the Environment and Infectious Inflammatory Lung Cystic Fibrosis

• Register: ClinicalTrials.gov
• Last refreshed on: 12 October 2015
• Main ID: NCT02564393
• Date of registration: 29/09/2015
• Prospective Registration: No
• Primary sponsor: University Hospital, Tours
• Public title: Induction of Neutrophilic Traps ( NETs ) by the Environment and Infectious Inflammatory Lung Cystic Fibrosis MucoNETs
• Scientific title: Secretion Induction of Neutrophil Extracellular Traps (NETs)in Inflammatory and Infectious Environment of Mucoviscidose
• Date of first enrolment: May 2011
• Target sample size: 55
• Recruitment status: Completed
• URL: https://clinicaltrials.gov/show/NCT02564393
• Study type: Observational
• Study design: Observational Model: Case Control, Time Perspective: Prospective

Countries of recruitment

France

Key inclusion & exclusion criteria

Inclusion Criteria:

Patients :

- Men or women over 18

- Patients with mucoviscidose in stable condition, i.e. not having presented an acute
push of bronchopulmonary attack requiring a antibiothérapie or a hospitalization for
treatment of its disease during the 2 previous weeks

- Signed consent

Volunteers :

- Men or women over 18

- Without respiratory antecedent nor known respiratory pathology

- Signed consent

Exclusion Criteria:

Patients :

- In exclusion period of an other study

Volunteers :

- In exclusion period of an other study

- Antibiotic treatment and/or anti-inflammatory drug (AINS or corticoids) in the 2
weeks before inclusion in the study



Age minimum: 18 Years
Age maximum: N/A
Gender: Both

Health Condition(s) or Problem(s) studied

Cystic Fibrosis

Primary Outcome(s)

the DNA concentration secreted into the extracellular environment neutrophil activated [Time Frame: 1 hour]

Secondary ID(s)

PHAO09-PD / MucoNETs

Source(s) of Monetary Support

Please refer to primary and secondary sponsors