Comparative Effect of Theipoental and Propofol in IVF Outcome

• Register: ClinicalTrials.gov
• Last refreshed on: 16 March 2015
• Main ID: NCT02377778
• Date of registration: 25/02/2015
• Prospective Registration: No
• Primary sponsor: Aristotle University Of Thessaloniki
• Public title: Comparative Effect of Theipoental and Propofol in IVF Outcome
• Date of first enrolment: January 2009
• Target sample size: 180
• Recruitment status: Completed
• URL: http://clinicaltrials.gov/show/NCT02377778
• Study type: Interventional
• Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment
• Phase: Phase 4

Countries of recruitment

Greece

Key inclusion & exclusion criteria

Inclusion Criteria:

- women undergoing oocyte retrieval for IVF under general anesthesia

- age =45 years

Exclusion Criteria:

- women with a known hypersensitivity to the active substance of the investigating
drugs or any of their excipients



Age minimum: 18 Years
Age maximum: 45 Years
Gender: Female

Health Condition(s) or Problem(s) studied

Subfertility

Intervention(s)

Drug: Propofol

Drug: Thiopental

Primary Outcome(s)

Fertilization rate [Time Frame: First 24h after oocyte retrieval]

Secondary Outcome(s)

Number of MII oocytes [Time Frame: 12h after oocyte rertieval]

Implantation rate [Time Frame: 40 days after embryo traansfer]

Pregnancy rate [Time Frame: 14 days after embryo transfer]

The concentration of propofol or thiopental in the follicular fluid of the dominant (larger) follicle aspirated at oocyte retrieval [Time Frame: 12 hours after oocyte retrieval]

Secondary ID(s)

UHR-8

Source(s) of Monetary Support

Please refer to primary and secondary sponsors