Extended-Release RANCAD in the Patients With Stable Angina Pectoris

• Register: ClinicalTrials.gov
• Last refreshed on: 16 December 2017
• Main ID: NCT02294942
• Date of registration: 14/11/2014
• Prospective Registration: No
• Primary sponsor: TSH Biopharm Corporation Limited
• Public title: Extended-Release RANCAD in the Patients With Stable Angina Pectoris
• Scientific title: A Double-blind, Randomized, Placebo-controlled, Parallel Study to Evaluate the Effects of add-on RANCAD on Exercise Tolerance and Angina Frequency in Patients With Stable Angina Pectoris.
• Date of first enrolment: October 2014
• Target sample size: 75
• Recruitment status: Completed
• URL: https://clinicaltrials.gov/show/NCT02294942
• Study type: Interventional
• Study design: Allocation: Randomized. Intervention model: Parallel Assignment. Primary purpose: Treatment. Masking: Triple (Participant, Care Provider, Investigator).
• Phase: Phase 3

Countries of recruitment

Taiwan

Contacts

• Name: Juey-Jen Hwang, M.D., Ph.D.,
• Affiliation: National Taiwan University Hospital

Key inclusion & exclusion criteria

Inclusion Criteria:

1. Male or female patients aged = 20 years old

2. A minimum 3-month history of stable angina

3. Patients with diagnosis of coronary artery disease (CAD)

4. Patients present with the symptoms of stable angina after withdrawn from other
antianginal drugs and given the required background therapy for at least 7 days will
be qualified for entering this study and performing 1st ETT qualifying test

5. Patients developed exercise-induced ECG ischemiai during two qualifying exercise
treadmill testsii. The difference between twoiii tests should be = 20% of the longer
test or = 1 minute i. Exercise-induced ECG ischemia is defined as the new development
of horizontal or down-sloping ST-segment depression of =1mm at 60-80ms after the J
point; if patients with baseline ST depression at rest (<1mm), qualifying ST segment
depression is defined as additional ST depression of at least 1 mm below the resting
value ii. Exercise treadmill test (ETT) will be performed by Modified Bruce Protocol.
iii. Two qualifying tests will be conducted 1 week apart, a 3rd ETT test will be
performed = 3 days when differences between previous two qualifying ETTs >20% of the
longer test or >1 minute

6. Willing and able to provide a written informed consent

Exclusion Criteria:

1. Factors that might compromise ECG or ETT interpretation

- Patients with resting ST-segment depression = 1mm in any lead

- Left bundle-branch block

- Patients implanted with pacemaker

- Patients under Digitalis therapy

2. Patients with family history of (or congenital) long QT syndrome

3. Patients with congenital heart disease

4. Patients with uncorrected valvular heart disease

5. Patients with unstable angina, or MI, or coronary revascularization procedure = 2
months prior enter this study

6. Female who is pregnant/lactating or planning to be pregnant, or female of childbearing
potential* who is not using medically recognized method of contraception

*Other than those who have been surgically sterilized (defined as having undergone
hysterectomy or bilateral oophorectomy or bilateral salpingectomy; tubal ligation
alone is not considered sufficient) or one year post-menopausal.

7. Patients are under any one of the following conditions:

- New York Heart Association (NYHA) Class III or Class IV congestive heart failure
(CHF)

- QTc > 450 msec at screening

- Active myocarditis, pericarditis, hypertrophic cardiomyopathy

- Uncontrolled hypertension (defined as SBP > 180 mmHg) Voltage criteria for left
ventricular hypertrophy in the absence of repolarization abnormalities will not
be exclusion criteria

8. Use of any investigational product = 4 weeks prior to screening

9. Patients with severe hepatic disease (e.g., liver cirrhosis)

10. Patients with impaired renal function (defined as serum Cr >1.5 mg/dl)

11. Patients with any condition or disease which is considered not suitable for this study
by investigator



Age minimum: 20 Years
Age maximum: N/A
Gender: All

Health Condition(s) or Problem(s) studied

Stable Angina Pectoris

Intervention(s)

Drug: RANCAD

Primary Outcome(s)

ETT performing at last treatment visit (Week 12). [Time Frame: Week 12 (not including screening & follow-up period)]

Secondary ID(s)

TSHRN1201

Source(s) of Monetary Support

Please refer to primary and secondary sponsors