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Main
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Note: This record shows only 22 elements of the WHO Trial Registration Data Set. To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register. |
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Register:
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ClinicalTrials.gov |
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Last refreshed on:
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19 February 2015 |
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Main ID: |
NCT02235584 |
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Date of registration:
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07/09/2014 |
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Prospective Registration:
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No |
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Primary sponsor: |
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Public title:
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Insulinotropic Effect of GLP-1 and GIP After Dexamethasone
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Scientific title:
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Loss of Insulinotropic Properties of Glucagon-like Peptide-1 (GLP-1) and Glucose-dependent Insulinotropic Peptide (GIP) After Glucocorticoid Induced Insulin Resistance |
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Date of first enrolment:
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July 2009 |
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Target sample size:
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19 |
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Recruitment status: |
Completed |
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URL:
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http://clinicaltrials.gov/show/NCT02235584 |
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Study type:
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Interventional |
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Study design:
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Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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Phase:
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N/A
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Countries of recruitment
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Denmark
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Contacts
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Name:
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Thure Krarup, dr. med. |
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Address:
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Telephone:
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Email:
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Affiliation:
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Bispebjerg Hospital |
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Key inclusion & exclusion criteria
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Inclusion Criteria:
- Caucasians above 20 and below 45 years of age
- Normal glucose tolerance as assessed by the WHO criteria
- First degree relative and at least 1 second degree relative with type 2 diabetes
- Normal haemoglobin
- Informed consent
Exclusion Criteria:
- Liver disease (ALAT/ASAT > 2 times normal value)
- Kidney disease (S-creatinin > 130uM and/or albuminuria)
- Heart disease (NYHA II, III or IV)
- Treatment with medicine that cannot be paused
- Pregnancy of breast feeding
Age minimum:
20 Years
Age maximum:
45 Years
Gender:
Both
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Health Condition(s) or Problem(s) studied
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Type 2 Diabetes
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Intervention(s)
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Drug: Dexamethasone
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Primary Outcome(s)
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The potentiating effects of GLP-1 on second phase insulin response when clamped at at bloodsugar of 7 mmol/l
[Time Frame: 1-3 days after dexamethasone treatment]
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Secondary Outcome(s)
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Second phase insulin response to GIP infusion at 7mmol/l
[Time Frame: 1-3 days after dexamethasone treatment]
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First phase insulin response to GIP infusion at 7mmol/l
[Time Frame: 1-3 days after dexamethasone]
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First phase insulin response to GLP-1 infusion at 7mmol/l
[Time Frame: 1-3 days after dexamethasone]
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Secondary ID(s)
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H-D-2009-070
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Source(s) of Monetary Support
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Please refer to primary and secondary sponsors
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Results
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Results available:
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Date Posted:
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Date Completed:
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URL:
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