The Relationship Between Sleep and Glucose Tolerance in Prediabetes: the Role of GLP-1 in Short Sleepers

• Register: ClinicalTrials.gov
• Last refreshed on: 16 December 2017
• Main ID: NCT02229487
• Date of registration: 28/08/2014
• Prospective Registration: Yes
• Primary sponsor: Ramathibodi Hospital
• Public title: The Relationship Between Sleep and Glucose Tolerance in Prediabetes: the Role of GLP-1 in Short Sleepers Sleep GLP-1
• Scientific title: The Relationship Between Sleep and Glucose Tolerance in Prediabetes: the Role of GLP-1 in Short Sleepers
• Date of first enrolment: October 2014
• Target sample size: 51
• Recruitment status: Completed
• URL: https://clinicaltrials.gov/show/NCT02229487
• Study type: Interventional
• Study design: Allocation: Non-Randomized. Intervention model: Parallel Assignment. Primary purpose: Diagnostic. Masking: None (Open Label).
• Phase: N/A

Countries of recruitment

Thailand

Key inclusion & exclusion criteria

Inclusion Criteria:

1. Patients with prediabetes (HbA1c 5.7-6.4% or history of fasting plasma glucose 100-125
mg/dl) who receive medical care at Ramathibodi Hospital

2. Age 18 or older

3. Can understand Thai (speaking, listening and reading)

4. Agree to participate by written informed consent

Exclusion Criteria:

1. Those who depend on others for feeding (such as stroke patients)

2. Shift workers

3. History of congestive heart failure or low ejection fraction

4. Chronic obstructive pulmonary disease, end stage renal disease or chronic liver
disease (AST or ALT > 3 times the upper limit of normal)

5. Use of medications: opioids/ narcotics , alpha blockers (prazosin, doxazosin,
terazosin), clonidine, methyldopa, nitroglycerin

6. Patients with permanent pacemaker

7. History of previous stroke



Age minimum: 18 Years
Age maximum: N/A
Gender: All

Health Condition(s) or Problem(s) studied

Prediabetes

Intervention(s)

Other: Oral glucose tolerance

Primary Outcome(s)

GLP-1 Levels in Response to Oral Glucose Tolerance Test [Time Frame: 2 weeks]

Secondary ID(s)

08-57-16

Source(s) of Monetary Support

Please refer to primary and secondary sponsors

Secondary Sponsor(s)

Merck Sharp & Dohme Corp.

Results

• Results available: Yes
• Date Posted: 14/08/2017
• URL: https://clinicaltrials.gov/ct2/show/results/NCT02229487