Antiplatelet Therapy After Cardiac Arrest

• Register: ClinicalTrials.gov
• Last refreshed on: 12 December 2020
• Main ID: NCT02224274
• Date of registration: 19/08/2014
• Prospective Registration: No
• Primary sponsor: University Medical Centre Ljubljana
• Public title: Antiplatelet Therapy After Cardiac Arrest
• Scientific title: Comparison of Antiplatelet Therapy With Clopidogrel and Ticagrelor in Patients After Cardiac Arrest Treated With Therapeutic Hypothermia
• Date of first enrolment: August 2014
• Target sample size: 57
• Recruitment status: Completed
• URL: https://clinicaltrials.gov/show/NCT02224274
• Study type: Interventional
• Study design: Allocation: Randomized. Intervention model: Parallel Assignment. Primary purpose: Treatment. Masking: None (Open Label).
• Phase: Phase 4

Countries of recruitment

Slovenia

Key inclusion & exclusion criteria

Inclusion Criteria:

- Female and male over 18 years old

- Unconscious survivors of cardiac arrest treated with therapeutic hypothermia

- Acute coronary syndrome (NSTEMI or STEMI) as a reason of cardiac arrest

- PCI with stent implantation

- Provision of informed consent prior to any study specific procedures is impossible
because subjects are unconscious at the moment of inclusion

Exclusion Criteria:

- Use of any P2Y12 inhibitors in last 10 days

- Use of prasugrel before and 48 hours after loading dose of P2Y12 inhibitor

- Use of eptifibatide before and 48 hours after loading dose of P2Y12 inhibitor

- Thrombocytopenia (<50*109/L)

- Allergic reaction to acetylsalicylic acid, clopidogrel or ticagrelor

- Ticagrelor contraindications: previous intracranial bleeding, active pathological
bleeding, moderate to severe hepatic impairment, heart rate < 40/min at presentation

- Suspected or confirmed pregnancy

- Use of bivalirudin before and 48 hours after loading dose of P2Y12 inhibitor



Age minimum: 18 Years
Age maximum: N/A
Gender: All

Health Condition(s) or Problem(s) studied

Postresuscitation Syndrome

Cardiac Arrest

Myocardial Infarction (ST-Elevation Myocardial Infarction and Non-ST-Elevation Myocardial Infarction)

Intervention(s)

Drug: Clopidogrel

Drug: Ticagrelor

Primary Outcome(s)

VerifyNow P2Y12Test - Platelet Reactivity [Time Frame: 12 h after P2Y12 inhibitor loading]

Secondary Outcome(s)

VerifyNow P2Y12Test - % Inhibition [Time Frame: 12 hours after P2Y12 inhibitor loading]

Multiplate ADP Test [Time Frame: 12 hours after P2Y12 inhibitor loading]

Secondary ID(s)

Hypothermia: Clopi vs Tica

Source(s) of Monetary Support

Please refer to primary and secondary sponsors

Results

• Results available: Yes
• Date Posted: 27/02/2019
• URL: https://clinicaltrials.gov/ct2/show/results/NCT02224274