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Main
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Note: This record shows only 22 elements of the WHO Trial Registration Data Set. To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register. |
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Register:
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ClinicalTrials.gov |
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Last refreshed on:
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19 February 2015 |
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Main ID: |
NCT02224040 |
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Date of registration:
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21/08/2014 |
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Prospective Registration:
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No |
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Primary sponsor: |
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Public title:
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Typhoid Fever: Combined vs. Single Antibiotic Therapy
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Scientific title:
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Typhoid Fever: Combined vs. Single Antibiotic Therapy. A Prospective Randomized Controlled Study in Nepal. |
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Date of first enrolment:
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August 2013 |
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Target sample size:
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120 |
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Recruitment status: |
Recruiting |
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URL:
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http://clinicaltrials.gov/show/NCT02224040 |
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Study type:
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Interventional |
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Study design:
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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Phase:
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Phase 4
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Countries of recruitment
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Nepal
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Contacts
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Name:
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Eli Schwartz, MD, DTMH |
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Address:
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Telephone:
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+97235308456 |
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Email:
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Eli.schwartz@sheba.health.gov.il |
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Affiliation:
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Name:
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Sudeep Shrestha, M.D |
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Address:
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Telephone:
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Email:
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itsactionpotential@gmail.com |
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Affiliation:
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Name:
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Eli Schwartz, MD, DTMH |
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Address:
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Telephone:
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Email:
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Affiliation:
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Sheba Medical Center |
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Key inclusion & exclusion criteria
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Inclusion Criteria:
- Blood culture-proven typhoid fever (S. typhi or S. paratyphi)
- Signed informed consent to participate in the study.
Exclusion Criteria:
- Allergy to ceftriaxone or macrolides
- Major typhoid fever-associated complications
- Inability to swallow oral medication
- Underlying illness
- Pregnancy
- Lactation
- Treatment within the past 4 days with an antibiotic that may be effective against
typhoid fever
Age minimum:
2 Years
Age maximum:
80 Years
Gender:
Both
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Health Condition(s) or Problem(s) studied
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Typhoid Fever
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Intervention(s)
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Drug: azithromycin
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Drug: azithromycin and cefixime
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Drug: ceftriaxone
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Drug: ceftriaxone and azithromycin
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Primary Outcome(s)
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Fever clearance time
[Time Frame: One month]
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Secondary Outcome(s)
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Treatment failure
[Time Frame: One month]
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Source(s) of Monetary Support
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Please refer to primary and secondary sponsors
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Results
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Results available:
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Date Posted:
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Date Completed:
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URL:
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