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Main
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Note: This record shows only 22 elements of the WHO Trial Registration Data Set. To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register. |
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Register:
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ClinicalTrials.gov |
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Last refreshed on:
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12 December 2020 |
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Main ID: |
NCT02105610 |
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Date of registration:
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02/04/2014 |
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Prospective Registration:
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Yes |
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Primary sponsor: |
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Public title:
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Volatile Anesthetics to Reduce Mortality in Cardiac Surgery
MYRIAD |
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Scientific title:
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Volatile Anesthetics to Reduce Mortality in Cardiac Surgery: A Multicentre Randomized Controlled Study |
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Date of first enrolment:
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April 14, 2014 |
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Target sample size:
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5400 |
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Recruitment status: |
Completed |
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URL:
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https://clinicaltrials.gov/show/NCT02105610 |
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Study type:
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Interventional |
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Study design:
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Allocation: Randomized. Intervention model: Parallel Assignment. Primary purpose: Treatment. Masking: Triple (Participant, Investigator, Outcomes Assessor).
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Phase:
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Phase 4
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Countries of recruitment
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Bahrain
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Brazil
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Bulgaria
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China
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Croatia
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Czech Republic
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Czechia
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Egypt
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Italy
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Malaysia
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Portugal
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Russian Federation
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Saudi Arabia
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Serbia
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Contacts
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Name:
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alberto zangrillo, Prof |
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Address:
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Telephone:
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Email:
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Affiliation:
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Vita-Salute University of Milano |
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Key inclusion & exclusion criteria
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Inclusion Criteria:
- age >18 years
- written informed consent
- scheduled procedures
- planned isolated CABG (multiple bypass are allowed; planned combined intervention such
as CABG plus valve surgery are not allowed
Exclusion Criteria:
- pregnancy
- planned valve surgery or surgery on the aorta
- planned locoregional anesthesia without general anesthesia
- unstable or ongoing angina
- recent (< 1 month) or ongoing acute myocardial infarction
- use of sulfonylurea, theophylline or allopurinol
- previous unusual response to an anesthetic agent
- inclusion in other randomised controlled studies in the previous 30 days
- any general anesthesia performed in the previous 30 days
- emergency operation (not scheduled)
- Kidney or liver transplant in medical history
- Liver cirrhosis (Child B or C)
Age minimum:
18 Years
Age maximum:
N/A
Gender:
All
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Health Condition(s) or Problem(s) studied
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Coronary Artery Bypass Grafting
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Cardiac Surgery
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Aortocoronary Bypass
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Intervention(s)
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Drug: desflurane, isoflurane, sevoflurane
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Drug: total intravenous anesthetics
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Primary Outcome(s)
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mortality
[Time Frame: 1 year]
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Secondary ID(s)
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VOLATILE/38/OSR
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Source(s) of Monetary Support
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Please refer to primary and secondary sponsors
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Results
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Results available:
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Date Posted:
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Date Completed:
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URL:
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