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Register:	ISRCTN
Last refreshed on:	11 February 2019
Main ID:	ISRCTN13030013
Date of registration:	04/02/2015
Prospective Registration:	No
Primary sponsor:	Ondokuz Mayis University
Public title:	Impact of smoking on gums
Scientific title:	Interleukin 8 and lipoxin a4 levels in the gingival crevicular fluid of smokers and non-smokers with different periodontal diseases: a cross-sectional study
Date of first enrolment:	01/09/2012
Target sample size:	30
Recruitment status:	Completed
URL:	http://isrctn.com/ISRCTN13030013
Study type:	Observational
Study design:	Cross-sectional observational study (Other)
Phase:

Countries of recruitment
Turkey

Contacts

Name:	Muge Lutfioglu
Address:	Ondokuz Mayis University Dental Faculty 55139 Samsun Turkey
Telephone:
Email:
Affiliation:

Name:
Address:
Telephone:
Email:
Affiliation:

Key inclusion & exclusion criteria

Inclusion criteria:
1. Smokers (= 5 years of duration and = 15 cigarettes per day)
2. Non-smokers (never smoked)
3. Age = 18 years old
4. = 16 teeth

Exclusion criteria:
1. History of cancer
2. History of rheumatoid arthritis
3. History of diabetes mellitus
4. History of cardiovascular diseases
5. Compromised immune system
6. Pregnancy
7. Menopause
8. Lactating
9. Ongoing drug therapy that may affect the clinical features of periodontitis
10. Systemic antimicrobials during the 6 weeks preceding the baseline examination
11. Any dental treatment during the past 6 months

Age minimum:
Age maximum:
Gender: Both

Health Condition(s) or Problem(s) studied

Periodontial disease is a leucocyte-mediated inflammatory disease characterised by inflammation of the supporting tissues of the teeth induced by micro-organisms that stimulate the host immune and inflammatory responses.
Oral Health
Periodontial disease

Intervention(s)

Gingival crevicular fluid samples will be obtained from the orifice of the gingival pocket, using commercially available periopaper strips for the assessment of:
1. Plaque index
2. Gingival index
3. Probing depth
4. Clinical attachment level
5. Bleeding on probing

Primary Outcome(s)

1. Silness and Loe plaque index
2. Loe and Silness gingival index
3. Probing pocket depth
4. Clinical attachment level
5. Bleeding on probing

Clinical measurements will be performed on six sites per tooth (mesio-buccal, mid-buccal, disto-buccal, mesio-lingual, mid-lingua and, disto-lingual) using a Williams periodontal probe calibrated in millimetres on the patient's first visit to have periodontal treatment.

Secondary Outcome(s)

Secondary ID(s)

Ref No: B.30.2.ANK.0.21.63.00/824-02/9-8

Source(s) of Monetary Support

Ondokuz Mayis University (Turkey)

Secondary Sponsor(s)

Ethics review

Status:
Approval date:
Contact:

Local ethics committee of the Dental School of Ankara University, 19/07/2011, reference number B.30.2.ANK.0.21.63.00/824-02/9-8

Results

Results available:	Yes
Date Posted:
Date Completed:	30/03/2014
URL:

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