The association of genetic variants and outcome of in vitro fertilization cycles

• Register: ISRCTN
• Last refreshed on: 27 February 2023
• Main ID: ISRCTN12768989
• Date of registration: 07/01/2016
• Prospective Registration: No
• Primary sponsor: Chung Shan Medical Unviersity Hospital
• Public title: The association of genetic variants and outcome of in vitro fertilization cycles
• Scientific title: The research of gene polymorphisms of hormonal signals genes in women entering in vitro fertilization program
• Date of first enrolment: 23/12/2013
• Target sample size: 2000
• Recruitment status: Completed
• URL: https://www.isrctn.com/ISRCTN12768989
• Study type: Observational
• Study design: Single-centre observational prospective cohort study (Screening)
• Phase: Not Applicable

Countries of recruitment

Taiwan

Contacts

• Name: Tsung-Hsien Lee

Key inclusion & exclusion criteria

Inclusion criteria:
1. Age 20 to 45 years old
2. Infertile patients who need IVF treatment
3. Qualified for IVF treatment

Exclusion criteria:
1. Part of the oocyte donation program
2. Part of the sperm donation program


Age minimum:
Age maximum:
Gender: Female

Health Condition(s) or Problem(s) studied

In vitro fertilization (IVF)
Pregnancy and Childbirth
In vitro fertilization (IVF)

Intervention(s)

All participating patients received controlled ovarian hyperstimulation protocols and oocyte retrieval procedures to get a number of oocytes. These oocytes were processed with in vitro fertilization/intracytoplasmic sperm injection to get embryos. Then we transferred the embryos back into the uterus. The duration of observation is at least one month. If a patient became pregnant, we followed her up for about one year until the delivery of baby.

Primary Outcome(s)

Oocyte number, measured using microscopy observation at the time of oocyte retrieval

Secondary Outcome(s)

1. Embryo quality is measured using microscopy observation for the number of blastomere, fragmentation degree at day 3 or day 5 after oocyte retrieval
2. Pregnancy rate is measured using serum beta-HCG test and ultrasound examination at 18 days and 32 days after oocyte retrieval, respectively
3. Implantation rate is measured using the total sac numbers divided by total transfer embryo number at the time of ultrasound examination

Secondary ID(s)

N/A

Source(s) of Monetary Support

Chung Shan Medical University Hospital

Ethics review

Status:
Approval date:
Contact:

Institutional Review Board of Chung Shan Medical University Hospital, 12/11/2013, ref: CS13194

Results

• Results available: Yes
• Date Completed: 15/12/2016