Effect of acupuncture on the DMN of brain in patients with major depressive disorder: a resting-state fMRI study

• Register: ChiCTR
• Last refreshed on: 18 April 2017
• Main ID: ChiCTR-OPC-15005873
• Date of registration: 2015-01-23
• Prospective Registration: No
• Primary sponsor: First Affiliated Hospital, Guangxi University of Chinese Medicine
• Public title: Effect of acupuncture on the DMN of brain in patients with major depressive disorder: a resting-state fMRI study
• Scientific title: Effect of acupuncture on the DMN of brain in patients with major depressive disorder: a resting-state fMRI study
• Date of first enrolment: 2012-06-01
• Target sample size: depressive group, healthy subjects:60;
• Recruitment status: Completed
• URL: http://www.chictr.org.cn/showproj.aspx?proj=10316
• Study type: Observational study
• Study design: Case-Control study
• Phase: Pilot study

Countries of recruitment

China

Contacts

• Name: Demao Deng

• Name: Demao Deng
• Affiliation: First Affiliated Hospital, Guangxi University of Chinese Medicine

Key inclusion & exclusion criteria

Inclusion criteria: All the MDD patients were individually diagnosed by two trained psychiatrists using the structured clinical interview of the Diagnostic and Statistical Manual of Mental Disorders-fourth criteria (DSM-IV) [32] and met the following criteria:
(1) first-episode, drug-na?ve;
(2) between the ages of 18 and 60 years;
(3) being right-handed; And
(4) currently episode experience of MDD with the score of at least 18 on 17-items Hamilton Depression Rating Scale (HDRS-17).
Exclusion criteria: (1) DSM-IV criteria for other diagnoses that included schizoaffective disorder, schizophrenia, organic mental disorders, delusional mental disorder, psychotic features coordinated or uncoordinated with mood or bipolar disorder;
(2) history of head injury or neurological disorder and degenerative diseases such as movement disorders and Parkinson’s disease);
(3) acutely suicidal or homicidal or requiring inpatient treatment;
(4) any MRI contraindications;
(5) all of acupuncture in patients with contraindications;
(6) assessment of acupuncture needling non-responders. All subjects did not smoke, no lactating women.

Age minimum: 19
Age maximum: 50
Gender: Both

Health Condition(s) or Problem(s) studied

depressive disorder

Intervention(s)

depressive group, healthy subjects:acupuncture at Baihui lasting 20min;

Primary Outcome(s)

activity in brain regions (ALFF, ReHo);Brain functional connectivity;

Source(s) of Monetary Support

the National Natural Science Foundation of China, the Guangxi Natural Science Foundation, the Guangxi Educational Commission Foundation