The effect of microparticles from the blood of sepsis patients on vascular leakage in rats.

• Register: ChiCTR
• Last refreshed on: 18 April 2017
• Main ID: ChiCTR-OOC-16008352
• Date of registration: 2016-04-24
• Prospective Registration: Yes
• Primary sponsor: State Key Laboratory of Trauma, Burns and Combined Injury, Department 2, Institute of Surgery Research, Third Military Medical University
• Public title: The effect of microparticles from the blood of sepsis patients on vascular leakage in rats.
• Scientific title: The role of vascular endothelial cell derived microparticles in vascular leakage after sepsis in rats
• Date of first enrolment: 2016-05-01
• Target sample size: Nomal control group and Sepsis patients group:20;
• Recruitment status: Recruiting
• URL: http://www.chictr.org.cn/showproj.aspx?proj=13800
• Study type: Observational study
• Study design: Case-Control study
• Phase: Other

Countries of recruitment

China

Contacts

• Name: Zheng Danyang
• Affiliation: Third Military Medical University

• Name: Liu Liangming
• Affiliation: Third Military Medical University

Key inclusion & exclusion criteria

Inclusion criteria: General variables
1. Fever (>38.3 degree C) or Hypothermia (core temperature <36 degree C);
2. Heart rate > 90/min–1 or more than two sd above the normal value for age;
3. Altered mental status;
4. Significant edema or positive fluid balance (>20 mL/kg over 24 hr);
5. Hyperglycemia (plasma glucose >140 mg/dL or 7.7 mmol/L) in the absence of diabetes.
Inflammatory variables:
1. Leukocytosis (WBC count >12,000 uL–1) or Leukopenia (WBC count <4000uL–1);
2. Plasma C-reactive protein more than two sd above the normal value.
Exclusion criteria: 1. History of chronic cardiovascular disease;
2. Pregnant woman or during the Menstrual period;
3. Malignant tumor or other severe disease.

Age minimum: 18
Age maximum: 80
Gender: Both

Health Condition(s) or Problem(s) studied

Sepsis

Intervention(s)

Nomal control group and Sepsis patients group:Collect venous blood 10ml.;

Primary Outcome(s)

Vascular leakage of rats.;

Source(s) of Monetary Support

National Natural Science Foundation of China(81570441)