Attributions andemotions – investigation of the transdiagnostic relationship anda randomized controlled trial on the effect of 4-session metacognitive training in Chinese adult outpatients with schizophrenia spectrum disorders andmajor depressive disorder

• Register: ChiCTR
• Last refreshed on: 18 April 2017
• Main ID: ChiCTR-IOR-15007166
• Date of registration: 2015-09-30
• Prospective Registration: Yes
• Primary sponsor: Department of Psychology, The Chinese University of Hong Kong
• Public title: Attributions andemotions – investigation of the transdiagnostic relationship anda randomized controlled trial on the effect of 4-session metacognitive training in Chinese adult outpatients with schizophrenia spectrum disorders andmajor depressive disorder
• Scientific title: Attributions andemotions – investigation of the transdiagnostic relationship anda randomized controlled trial on the effect of 4-session metacognitive training in Chinese adult outpatients with schizophrenia spectrum disorders andmajor depressive disorder
• Date of first enrolment: 2015-10-06
• Target sample size: Two groups:180;Description of the treatment:0;(to be continued):0;(to be continued):0;(to be continued):0;(to be continued):0;
• Recruitment status: Pending
• URL: http://www.chictr.org.cn/showproj.aspx?proj=12059
• Study type: Interventional study
• Study design: Randomized parallel controlled trial
• Phase: Other

Countries of recruitment

China

Contacts

• Name: Wong Hau Lam
• Affiliation: Department of Psychology, The Chinese University of Hong Kong

• Name: Prof. So Ho-wai Suzanne

Key inclusion & exclusion criteria

Inclusion criteria: Delusion group: non-organic psychosis with active delusions.
Depression group: major depressive disorder, received treatment for at least 1 month, with active depressive symptoms (moderate depression, with BDI-II score around 20 or above).
Exclusion criteria: Psychotic depression;
Depression with psychotic features;
Bipolar disorder;
Primary diagnosis of substance misuse;
Learning disability;
Participation in any cognitive/ reasoning training program.

Age minimum: 18
Age maximum: 65
Gender: Both

Health Condition(s) or Problem(s) studied

Psychosis, Depression

Intervention(s)

Two groups:4-session Metacognitive training (MCT) once a week for four weeks versus Treatment as usual (TAU);Description of the treatment:1. Treatment condition - 4 weeks of Metacognitive training (MCT) in groups of 6-8 members, with training targetting at reasoning bias relevant to those observed in depression andpsychosis. The attribution training will consist of 4 sessions from the Chinese MCT protocol: module 1 (“Attributions”), module 3 (“Changing beliefs”), module 4 (“To empathise”) andmodule 8 (“Self-esteem andmood”). ;(to be continued):Module 1 specifically targets internal andexternal attributions in both positive andnegative events, andexplicitly links these to both depression anddelusions. Modules 3 and4 challenge ‘first impressions’ andfocus on the importance of considering evidence that does not support one’s original beliefs. ;(to be continued):Module 8 educates patients about depressive cognition – including internalising bias andselective attention, etc. – andtheir link to low mood andself-esteem. Therapeutic exercises in this module draw from the positive psychology approaches, namely optimism, positive attention andmemory, andthanksgiving.;(to be continued):2. Treatment as usual (TAU) condition - 4 weeks of standard care (psychiatric follow-up andpharmacological intervention) from their psychiatric clinics. Patients on the TAU condition will not be receiving any psychological treatment concurrently. ;(to be continued):Assessments will take place before TAU, after 4 weeks of TAU, with follow-ups after 1 and6 months.;

Primary Outcome(s)

Attributional style, measured by 1. Internal, Personal andSituational Attributions Questionnaire; 2. Attributional Style Questionnaire; 3. Daily diary method for 7 days; 4. Personal significance scale (PSS);Symptomatology for psychotic group measured by 1. Positive andNegative Syndrome Scale; 2. The Psychotic Symptom Rating Scale; 3. Calgary Depression Scale; 4. Generalised Anxiety Disorder 7;Symptomatology for depression group, measured by 1. Beck Depression Inventory – II; 2. Generalised Anxiety Disorder 7;Belief Flexibility, measured by 1. Maudsley Assessment of Delusions Schedule; 2. Explanation of Experience; 3. BADE task.;Emotional states (Depression, Anger, Anxiety), measured by State-Trait Personality Inventory;

Secondary Outcome(s)

Executive functioning measured by Trail making test (TMT);Intellectual functioning measured by Wechsler Adult Intelligence Scale (WAIS)-III Chinese version;Psychiatric diagnosis measured by Structured Clinical Interview for DSM.;

Secondary ID(s)

CUHK_CCRB00480

Source(s) of Monetary Support

Non-commerical funding source: Croucher Foundation