The Influence of Emotional Stress on Brain Activity and Brain Functional Connection in the Patients with IBS Associated with ELA

• Register: ChiCTR
• Last refreshed on: 22 May 2017
• Main ID: ChiCTR-COC-17011335
• Date of registration: 2017-05-08
• Prospective Registration: No
• Primary sponsor: Department of Gastroenterology,Tongji Hospital affiliated to Tongji University
• Public title: The Influence of Emotional Stress on Brain Activity and Brain Functional Connection in the Patients with IBS Associated with ELA
• Scientific title: Study on the Change of Brain Activity and Brain Functional Connection in the Patients with IBS Associated with ELA
• Date of first enrolment: 2016-06-01
• Target sample size: EIA related IBS:15;EIA non-related IBS:15;Normal control:15;
• Recruitment status: Recruiting
• URL: http://www.chictr.org.cn/showproj.aspx?proj=18867
• Study type: Cause
• Study design: Case-Control study
• Phase: Other

Countries of recruitment

China

Contacts

• Name: Shuchang Xu
• Affiliation: Department of Gastroenterology, Tongji Hospital affiliated to Tongji University

• Name: Yuan Lin
• Affiliation: Department of Gastroenterology, Tongji Hospital affiliated to Tongji University

Key inclusion & exclusion criteria

Inclusion criteria: Irritable bowel syndrome group inclusion criteria:
1. aged 18 to 70 years old, male or female;
2. right-handed;
3. all patients had abdominal pain with bowel habits or stool change characteristics, persistently or intermittently;
4. by gastrointestinal endoscopy, abdominal ultrasound, CT, MRI and other related biochemical imaging check and check, the results were not found related to pathological changes;
5. Symptoms appeared at least 6 months,in nearly 3 months, symptoms consistent with the above criteria;
The normal group inclusion criteria:
1. aged 18 to 70 years old, male or female;
2. right-handed;
3. No symptoms of digestive tract and disease history in the last 6 months.
Exclusion criteria: 1. other digestive tract diseases were evaluated by digestive medicine;
2. history of alcohol or tobacco abuse;
3. patients with other brain injury such as intracranial tumors, stroke history;
4. suffering from mental illness;
5. patients with metallic implants;
6. have serious heart, liver or kidney diseases.

Age minimum: 18
Age maximum: 70
Gender: Both

Health Condition(s) or Problem(s) studied

Irritable Bowel Syndrome

Intervention(s)

EIA related IBS:emotional picture stimuli;EIA non-related IBS:emotional picture stimulity;Normal control:emotional picture stimulity;

Primary Outcome(s)

brain activity and functional connection;

Source(s) of Monetary Support

no