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Main
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Note: This record shows only 22 elements of the WHO Trial Registration Data Set. To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register. |
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Register:
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ChiCTR |
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Last refreshed on:
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22 May 2017 |
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Main ID: |
ChiCTR-COC-17011332 |
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Date of registration:
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2017-05-08 |
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Prospective Registration:
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Yes |
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Primary sponsor: |
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Public title:
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Epigentic susceptibility mechanisms of postoperative cognitive dysfunction
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Scientific title:
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The role of GR gene methylation associated with inflammation disregulation on epigentic susceptibility mediated POCD development |
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Date of first enrolment:
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2017-05-20 |
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Target sample size:
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Case series:150; |
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Recruitment status: |
Recruiting |
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URL:
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http://www.chictr.org.cn/showproj.aspx?proj=19313 |
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Study type:
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Cause |
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Study design:
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Cohort study
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Phase:
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Other
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Countries of recruitment
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China
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Contacts
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Name:
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Liwei Wang
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Address:
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199 South Jiefang Road, Jiangsu, China
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Telephone:
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+86 18952170255 |
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Email:
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doctorlww@sina.com |
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Affiliation:
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Xuzhou Central Hospital |
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Name:
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Yangzi Zhu
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Address:
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199 South Jiefang Road, Jiangsu, China
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Telephone:
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+86 15862149539 |
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Email:
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1270011345@qq.com |
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Affiliation:
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Xuzhou Central Hospital |
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Key inclusion & exclusion criteria
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Inclusion criteria: Eligible subjects were ASA I or II patients between 65 and 75 years of age, scheduled for total knee arthroplasty or hip replacement.
Exclusion criteria: Mini-Mental State Examination (MMSE) score<23;; peptic ulcer disease, cardiac-cerebral vascular disease, diabetes mellitus; neurological or psychiatric disorders; history of allergic reactions to NSAIDs; history of drug and alcohol abuse; hepatic and/or kidney dysfunction; BMI>35; patients on analgesics or antidepressants; inability to comply with the study protocol or procedures.
Age minimum:
65
Age maximum:
75
Gender:
Both
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Health Condition(s) or Problem(s) studied
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postoperative cognitive dysfunction
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Intervention(s)
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Case series:Nil;
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Primary Outcome(s)
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Postoperative cognitive function;Glucocorticoid receptor level;levels of glucocorticoid receptor gene methylation;plasma levels of pro-inflammatory cytokines;other outcome according to the experimental instances;
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Source(s) of Monetary Support
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self-raised funds
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Results
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Results available:
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Date Posted:
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Date Completed:
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URL:
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