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Main
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Note: This record shows only 22 elements of the WHO Trial Registration Data Set. To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register. |
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Register:
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ANZCTR |
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Last refreshed on:
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18 June 2018 |
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Main ID: |
ACTRN12618000969268 |
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Date of registration:
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08/06/2018 |
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Prospective Registration:
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No |
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Primary sponsor: |
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Public title:
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Effect of Perioperative Single-Dose Oral Pregabalin and Intravenous Ibuprofen Combination Administration for Postoperative Pain After Third Molar Surgery
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Scientific title:
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Comparisons the effects of preventive intravenous ibuprofen infusion and the combinations of intravenous ibuprofen infusion together with 2 different single oral dose of pregabalin on the postoperative pain after mandibular third molar extractions under local anesthesia |
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Date of first enrolment:
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1/03/2016 |
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Target sample size:
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76 |
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Recruitment status: |
Completed |
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URL:
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http://www.anzctr.org.au/ACTRN12618000969268.aspx |
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Study type:
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Interventional |
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Study design:
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Randomised controlled trial
Parallel |
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Phase:
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Phase 4
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Key inclusion & exclusion criteria
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Health Condition(s) or Problem(s) studied
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impacted third molar
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perioperative analgesia
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Intervention(s)
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Single-Dose Oral Pregabalin and Intravenous Ibuprofen Combination Administration before oral surgery. The treatment groups included the following: (Group 1) premedicated with oral placebo and intravenous (IV) placebo, (Group 2) premedicated with oral placebo and 400 mg IV Ibuprofen, (Group 3) premedicated with 75 mg oral pregabalin and 400 mg IV ibuprofen, and (Group 4) premedicated with 150 mg oral pregabalin and 400 mg IV ibuprofen.
Oral pregabalin (75 or 150 mg) (Lyrica; Pfizer, Inc., New York, NY) and oral placebo (using similar looking cornstarch capsules) were administered to the corresponding treatment groups one hour before surgery. Intravenous ibuprofen (400 mg) (Intrafen; Gen Pharmaceuticals, Istanbul, Turkey) and intravenous placebo (sterile saline solution) were administered via intravenous infusion 30 minutes before surgery
The medications were administered by a nurse who supervised by the director of the department, from the oral and maxillofacial surgery department.
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Source(s) of Monetary Support
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Results
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Results available:
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Date Posted:
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Date Completed:
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URL:
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