A study looking at the reproducibility of Magnetic Resonance Imaging (MRI) Simulation Scans for Radiotherapy Planning

• Register: ANZCTR
• Last refreshed on: 7 June 2021
• Main ID: ACTRN12616000523404
• Date of registration: 22/04/2016
• Prospective Registration: No
• Primary sponsor: Liverpool Hospital
• Public title: A study looking at the reproducibility of Magnetic Resonance Imaging (MRI) Simulation Scans for Radiotherapy Planning
• Scientific title: Uncertainty in Magnetic Resonance Imaging (MRI) Simulation Scans for Radiotherapy Planning
• Date of first enrolment: 03/03/2016
• Target sample size: 60
• Recruitment status: Completed
• URL: https://anzctr.org.au/ACTRN12616000523404.aspx
• Study type: Observational
• Study design: Purpose: Natural history;Duration: Cross-sectional;Selection: Defined population;Timing: Prospective;
• Phase: Not Applicable

Countries of recruitment

Australia

Contacts

• Name: Prof Shalini Vinod

• Name: Prof Shalini Vinod

Key inclusion & exclusion criteria

Inclusion criteria: - Aged 18 years or older
- Patients undergoing a planning MRI for their radiotherapy treatment or research purposes for prostate, head and neck, central nervous system, rectal, lung or cervix cancer
Exclusion criteria: - Patient refusal
- Contraindication to MRI, such as pacemakers and embodied metal objects, as assessed with the MRI Safety Questionnaire
- Patients with severe claustrophobia or who are unable to lie still
- Inability to give informed consent

Age minimum: 18 Years
Age maximum: No limit
Gender: Both males and females

Health Condition(s) or Problem(s) studied

Cancer - Cervical (cervix)

Cancer - Other cancer types

Cancer - prostate;Cancer - head and neck;Cancer - central nervous system;Cancer - rectal;Cancer - lung ;Cancer - cervix. ;
Cancer - prostate
Cancer - head and neck
Cancer - central nervous system
Cancer - rectal
Cancer - lung
Cancer - cervix.

Cancer - Prostate

Intervention(s)

The intervention involves an additional MRI scan for participants that will only be used for the purpose of the study and not for the radiotherapy treatment planning. Participants would otherwise be attending for an MRI scan for the purposes of planning for their radiotherapy treatment (simulation) but the intervention is an additional scan. The scan will be performed by a suitably qualified allied health professional. The scan will be performed at only one time point and on the same day as their radiotherapy planning MRI or clinical research MRI and the additional scan will take approximately 15 minutes.
The additional MRI scan will be completed with fewer sequences than the first scan. The sequences used will be one anatomical and one functional imaging sequence (DWI).

Primary Outcome(s)

To assess the consistency of imaging information considering the magnitude and consistency of anatomical and Diffusion Weighted Imaging (DWI) distortion. This will be assessed through the acquisition of 2 MRI sets of scans which will be fused and compared to determine the consistency of imaging and impact of MRI distortion, landmark positions and contours. [At time of MRI scan]

To assess the reproducibility of Magnetic resonance Imaging (MRI) setup in the radiotherapy position. This will be assessed through the acquisition of 2 MRI sets of scans which will be fused and compared to determine the consistency of imaging and impact of MRI distortion, landmark positions and contours. [At time of MRI scan]

Secondary Outcome(s)

None[None]

Secondary ID(s)

None

Source(s) of Monetary Support

Liverpool Cancer Services Trust Fund

Secondary Sponsor(s)

A/Prof Shalini Vinod

Ethics review

Status: Approved
Approval date: 14/12/2015
Contact:

South Western Sydney Local Health District

Results

• Results available: Yes
• Date Posted: 28/10/2019
• Date Completed: 05/04/2017