The Fluid Translation of Research into Practice Study - Discrete Choice Experiment (Survey) of Intensive Care clinicians preferences of resuscitation fluid.

• Register: ANZCTR
• Last refreshed on: 13 January 2020
• Main ID: ACTRN12615000031561
• Date of registration: 19/01/2015
• Prospective Registration: Yes
• Primary sponsor: The George Institute for Global Health
• Public title: The Fluid Translation of Research into Practice Study - Discrete Choice Experiment (Survey) of Intensive Care clinicians preferences of resuscitation fluid.
• Scientific title: Discrete choice experiment to understand what drives intensive care clinicians' choice of fluid type used for fluid resuscitation in intensive care patients
• Date of first enrolment: 14/08/2015
• Target sample size: 352
• Recruitment status: Completed
• URL: https://anzctr.org.au/ACTRN12615000031561.aspx
• Study type: Observational
• Study design: Purpose: Screening;Duration: Cross-sectional;Selection: Convenience sample;Timing: Prospective;
• Phase: Not Applicable

Countries of recruitment

Australia, Belgium, Brazil, Canada, Chile, China, Denmark, France, Germany, Hong Kong, Ireland, Italy, Japan, Monaco, New Zealand, Singapore, South Africa, Sweden, Switzerland, United Arab Emirates, United States of America

Contacts

• Name: Dr Colman Taylor

• Name: Dr Colman Taylor

Key inclusion & exclusion criteria

Inclusion criteria: Intensive Care Clinician at participating hospital
Exclusion criteria: Nil

Age minimum: No limit
Age maximum: No limit
Gender: Both males and females

Health Condition(s) or Problem(s) studied

Critical Illness;Hypovolemia;Fluid resuscitation;
Critical Illness
Hypovolemia
Fluid resuscitation

Public Health - Health service research

Intervention(s)

The aim of this study is to define and understand the fundamental drivers of fluid resuscitation choice for critically ill patients. The study uses a scenario based survey of clinician preferences using the Discrete Choice Experiment (DCE) methodology. The survey will be administered online via a secure database and will take each clinician approximately 20-30 minutes to complete. The study period is anticipated to run for 2-3 months.

Primary Outcome(s)

The primary objective of this study is to identify key attributes that have the largest influence on the choice of fluid used for resuscitation.

The statistical analysis of the DCE data will involve a mixed multinomial (randoms parameters) logit model (MMNL) using a panel size specification. [Within 6 months of completion of the Fluid TRIPS Study
Australian New Zealand Clinical Trials Registry, Number:ACTRN12613001172796 ]

Secondary Outcome(s)

The secondary objective is to describe a “willingness to spend” threshold (by international region) where clinicians will switch from less expensive preparations to more expensive preparations.

The analysis will enable: 1) estimates of the marginal effect of each attribute, and respondent characteristic on choice of resuscitation fluid; 2) the relative tradeoff (or marginal rate of substitution) between attributes, in particular the calculation of clinician “willingness to spend” thresholds, and 3) predictions to be made of the preference for current resuscitation fluids.[Within 6 months of completion of the Fluid TRIPS Study Australian New Zealand Clinical Trials Registry, Number:ACTRN12613001172796 ]

Secondary ID(s)

Nil known

Source(s) of Monetary Support

The George Institute for Global Health

Ethics review

Status: Approved
Approval date:
Contact:

Sydney Local Health District Ethics Review Committee (RPAH Zone)