Effect Of Two Doses Of Magnesium Sulfate On Hemodynamic Stability During Induction And Orotracheal Intubation In Adult Diabetic Patients

• Register: ANZCTR
• Last refreshed on: 13 January 2020
• Main ID: ACTRN12614001012662
• Date of registration: 19/09/2014
• Prospective Registration: Yes
• Primary sponsor: dr doaa rashwan
• Public title: Effect Of Two Doses Of Magnesium Sulfate On Hemodynamic Stability During Induction And Orotracheal Intubation In Adult Diabetic Patients
• Scientific title: Effect Of Two Doses Of Magnesium Sulfate On Hemodynamic Stability During Induction And Orotracheal Intubation In Adult Diabetic Patients
• Date of first enrolment: 11/11/2015
• Target sample size: 50
• Recruitment status: Completed
• URL: https://anzctr.org.au/ACTRN12614001012662.aspx
• Study type: Interventional
• Study design: Purpose: Prevention; Allocation: Randomised controlled trial;
• Phase: Phase 2

Countries of recruitment

Egypt

Contacts

• Name: Dr doaa rashwan

• Name: Dr doaa rashwan

Key inclusion & exclusion criteria

Inclusion criteria: 50 ASA II males and females patients aged 40-65 years old, with controlled type II diabetes mellitus planned for elective surgery under general anesthesia requiring orotracheal intubation.
Exclusion criteria: Patients will be excluded from the study if they had history of
type I diabetes mellitus, hypertension, cardiac disease, hypomagnesemia or hypermagenesmia , a known allergy to the study drugs, neuromuscular, liver and renal diseases ,suspected or history of difficult intubation, prolonged intubation longer than 30 secs or more than one attempt required, BMI >30 .
Patients undergoing cardiac and neurosurgical procedures will be also excluded.


Age minimum: 40 Years
Age maximum: 65 Years
Gender: Both males and females

Health Condition(s) or Problem(s) studied

Anaesthesiology - Anaesthetics

Diabetes;Hemodynamic Stability During Induction And Orotracheal Intubation;
Diabetes
Hemodynamic Stability During Induction And Orotracheal Intubation

Metabolic and Endocrine - Diabetes

Intervention(s)

The patients will be randomly divided using closed envelope
technique for randomization to one of two groups:
M 30 group ( n = 25): will receive intravenous magnesium sulfate 30 mg/kg added to 100 ml of normal saline over 15 minutes before induction of general anesthesia
M 50 ( n =25): will receive intravenous magnesium sulfate 50 mg/kg

added to 100 ml of normal saline over 15 minutes before induction of general anesthesia

Primary Outcome(s)

diastolic arterial blood pressure
noninvasive monotoring[ will be measured and recorded:
a- Before the administration of the study drug at baseline
b-after induction of anesthesia
c –at 1,5,10 minutes following tracheal intubation and before skin incision.
]

mean arterial blood pressure
noninvasive monotoring[will be measured and recorded:
a- Before the administration of the study drug at baseline
b-after induction of anesthesia
c –at 1,5,10 minutes following tracheal intubation and before skin incision.
]

The systolic arterial blood pressure
noninvasive monotoring[will be measured and recorded:
a- Before the administration of the study drug at baseline
b-after induction of anesthesia
c –at 1,5,10 minutes following tracheal intubation and before skin incision.
]

Secondary Outcome(s)

heart rate
ECG [ will be measured and recorded:
a- Before the administration of the study drug at baseline
b-after induction of anesthesia
c –at 1,5,10 minutes following tracheal intubation and before skin incision.
]

Secondary ID(s)

nil

Source(s) of Monetary Support

dr doaa rashwna

Ethics review

Status: Approved
Approval date:
Contact:

benisuef ethical comitee