Measuring Collaterals With Multi-phase CT Angiography in Patients With Ischemic Stroke

• Register: ClinicalTrials.gov
• Last refreshed on: 16 December 2017
• Main ID: NCT02184936
• Date of registration: 03/07/2014
• Prospective Registration: No
• Primary sponsor: Carol Kenney
• Public title: Measuring Collaterals With Multi-phase CT Angiography in Patients With Ischemic Stroke PRove-IT
• Scientific title: Precise and Rapid Assessment of Collaterals Using Multi-phase CTA in the Triage of Patients With Acute Ischemic Stroke for IA Therapy
• Date of first enrolment: September 2012
• Target sample size: 500
• Recruitment status: Completed
• URL: https://clinicaltrials.gov/show/NCT02184936
• Study type: Observational
• Phase: N/A

Countries of recruitment

Canada, Italy

Contacts

• Name: Bijoy Menon, MD
• Affiliation: University of Calgary, Calgary Stroke Program

Key inclusion & exclusion criteria

Inclusion Criteria:

1. Patient presenting to the emergency department with symptoms consistent with ischemic
stroke.

2. Age > 18 yrs.

3. Baseline imaging including multi-phase CTA done within 12 hours of stroke symptom
onset and initiated before recanalization therapy.

4. Evidence of a visible and symptomatic intracranial occlusion on baseline
CT-angiography (intracranial ICA, M1 MCA segment +/- intracranial ICA, proximal M2
MCA).

5. Treatment with IV tPA and/or IA therapy.

Exclusion Criteria:

1. Intracranial hemorrhage (ICH) identified on baseline CT.

2. Previous moderate to large stroke in the ipsilesional hemisphere.

3. Modified Rankin Scale > 2 at baseline.

4. Unable to have CT-angio performed due to recent estimated creatinine clearance eCCr<60
ml/min, contrast allergy or other reasons.

5. Participation in another study that results in the patient receiving an
investigational drug or therapy.

6. Any terminal illness (patient not expected to survive > 1 year).



Age minimum: 18 Years
Age maximum: N/A
Gender: All

Health Condition(s) or Problem(s) studied

Ischemic Stroke

Intervention(s)

Other: standard of care

Primary Outcome(s)

Major neurological improvement at 24 hours [Time Frame: 24 hours post stroke onset]

Secondary Outcome(s)

90 day clinical outcome [Time Frame: 90 days]

Radiological outcome [Time Frame: 24 hours]

percent neurologic improvement comparing NIHSS at baseline to 24 hours [Time Frame: 24 hours]

90-day NIHSS score 0-2 [Time Frame: 90 days]

Secondary ID(s)

24416

Source(s) of Monetary Support

Please refer to primary and secondary sponsors