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Note: This record shows only 22 elements of the WHO Trial Registration Data Set. To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register.

Register:	ClinicalTrials.gov
Last refreshed on:	21 February 2022
Main ID:	NCT01905436
Date of registration:	12/07/2013
Prospective Registration:	No
Primary sponsor:	Washington University School of Medicine
Public title:	Mass Drug Administration for Lymphatic Filariasis and Onchocerciasis for Liberia DOLF-LIBERIA
Scientific title:	Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis for Liberia
Date of first enrolment:	March 2012
Target sample size:	21862
Recruitment status:	Completed
URL:	https://clinicaltrials.gov/show/NCT01905436
Study type:	Observational
Study design:
Phase:

Countries of recruitment
Liberia

Contacts

Name:	Peter U Fischer, PhD
Address:
Telephone:
Email:
Affiliation:	Washington University School of Medicine

Name:	Fatorma K Bolay, PhD
Address:
Telephone:
Email:
Affiliation:	Liberian Institute of Biomedical Research

Name:	Gary J Weil, MD
Address:
Telephone:
Email:
Affiliation:	Washington University School of Medicine

Key inclusion & exclusion criteria

Inclusion Criteria:

- • Study areas should be endemic for filariasis and onchocerciasis.

- • Study population have limited or no prior experience with MDA. Males and Females
greater than 5 years of age.

Exclusion Criteria:

- • Children less than 5 years of age.

- • Children who weigh less than 15 kg (33 lb)

Age minimum: 5 Years
Age maximum: N/A
Gender: All

Health Condition(s) or Problem(s) studied

Onchocerciasis

Lymphatic Filariasis

Soil Transmitted Helminth (STH) Infections

Intervention(s)

Drug: Annual versus Semiannual Albendazole plus Ivermectin Mass Drug Administration

Primary Outcome(s)

Prevalence of W. bancrofti filarial antigenemia (4 years) [Time Frame: 4 years]

Prevalence of W. bancrofti microfilaria (4 years) [Time Frame: 4 years]

Secondary Outcome(s)

Prevalence of O. volvulus microfilaria (4 years) [Time Frame: 4 years]

Prevalence of W. bancrofti filarial antigenemia (7 years) [Time Frame: 7 years]

Prevalence of W. bancrofti microfilaria (7 years) [Time Frame: 7 years]

Community egg load of soil transmitted helminth (STH) eggs (7 years) [Time Frame: 7 years]

Community egg load of soil transmitted helminth (STH) eggs (4 years) [Time Frame: 4 years]

Prevalence of O. volvulus microfilaria (7 years) [Time Frame: 7 years]

Secondary ID(s)

201107185

Source(s) of Monetary Support

Please refer to primary and secondary sponsors

Secondary Sponsor(s)

Ethics review

Results

Results available:
Date Posted:
Date Completed:
URL:

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