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Main
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Note: This record shows only 22 elements of the WHO Trial Registration Data Set. To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register. |
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Register:
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ISRCTN |
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Last refreshed on:
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28 November 2016 |
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Main ID: |
ISRCTN43007027 |
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Date of registration:
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07/02/2011 |
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Prospective Registration:
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No |
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Primary sponsor: |
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Public title:
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Functional anatomy and impact of cognitive training on chunking within working memory in early Alzheimer's disease
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Scientific title:
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Functional anatomy and impact of cognitive training on chunking within working memory in early Alzheimer's disease: a randomised controlled trial |
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Date of first enrolment:
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20/12/2010 |
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Target sample size:
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30 |
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Recruitment status: |
Completed |
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URL:
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http://isrctn.com/ISRCTN43007027 |
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Study type:
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Interventional |
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Study design:
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Randomised controlled trial (Quality of life)
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Phase:
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Not Applicable
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Countries of recruitment
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United Kingdom
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Contacts
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Name:
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Address:
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Telephone:
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Email:
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Affiliation:
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Name:
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Jonathan
Huntley |
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Address:
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Institute of Psychiatry
De Crespigny Park
SE5 8AZ
London
United Kingdom |
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Telephone:
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Email:
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Affiliation:
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Key inclusion & exclusion criteria
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Inclusion criteria: 1. Aged greater than 60 years, either sex
2. Diagnosis of probable Alzheimer's disease according to National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria
3. Mini-Mental State Examination (MMSE) score greater than 23/30
4. All subjects will be required to provide informed consent to participate in the study
Exclusion criteria: 1. Co-existent neurological or psychiatric disease
2. Substance misuse
3. Significant auditory or visual impairment
Age minimum:
Age maximum:
Gender:
Both
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Health Condition(s) or Problem(s) studied
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Early Alzheimer's disease
Nervous System Diseases
Alzheimer's disease
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Intervention(s)
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Subjects will be randomly allocated to either a cognitive training group or control group. The cognitive training group will undergo 18 days of training over 6 weeks for approximately 45 minutes/day. Each training session will consist of 30 trials of structured span tasks. The length of span will be adjusted after each trial depending on whether it is correctly recalled. Each subject will therefore be continually tested at their span limit, which can adjust both within and across sessions. The control group will perform 30 trials of a 2 span unstructured task over the same time period. After 6 weeks of training, subjects will be reassessed using the baseline battery of tasks, and re-imaged with functional magnetic resonance imaging (fMRI) performing the same verbal chunking task protocol.
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Primary Outcome(s)
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1. Scores on verbal working memory task
2. Cerebral blood flow in the prefrontal and parietal cortices as measured using fMRI
Measured at baseline and after 8 weeks (following the 6 week cognitive training intervention).
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Secondary Outcome(s)
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Scores on:
1. Spatial working memory task
2. Sustained attention, reasoning and episodic memory tasks
3. Artificial grammar task
4. Instrumental activities of daily living (ADL) task
Measured at baseline and after 8 weeks (following the 6 week cognitive training intervention).
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Secondary ID(s)
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Version 1 (13.7.10); G0901982
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Source(s) of Monetary Support
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Medical Research Council (MRC) (UK) (ref: G0901982/ ID 93849)
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Results
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Results available:
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Date Posted:
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Date Completed:
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URL:
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