New in RHL

Amnioinfusion for third trimester preterm premature rupture of membranes

The effects of amnioinfusion for preterm premature rupture of membranes (PPROM) are limited by the small sample sizes of the included studies.

Antibiotics for incomplete abortion

There is a lack of research evidence on the effectiveness of routine antibiotic prophylaxis for women with incomplete abortion and more research is needed.

Vasectomy occlusion techniques for male sterilization

There is insufficient evidence to conclude on the effectiveness, safety, acceptability and costs of different vasectomy occlusion techniques for male sterilization.

Antibiotics for preterm rupture of membranes

Administration of antibiotics to women with PROM is associated with short-term delay in delivery and reduction in maternal and neonatal morbidity. However, in the longer-term antibiotic use for PROM has little effect.

Calcium channel blockers for inhibiting preterm labour and birth

Administration of calcium channel blockers (CCB) to women in preterm labour is associated with a significant reduction in preterm birth and short-term reduction in neonatal morbidity. However, no differences in perinatal mortality and in long-term outcomes were seen. Available data do not allow firm conclusions to be drawn from this review.

Immediate postpartum insertion of intrauterine device for contraception

Immediate insertion (within 10 minutes of placenta delivery) may increase rates of intrauterine device (IUD) use compared to later placement, but may be associated with an increased rate of expulsion.

Traditional birth attendant (TBA) training for improving health behaviours and pregnancy outcomes

There is significant reduction in stillbirth, perinatal and neonatal mortality in the trained versus untrained TBA clusters. However, no clear benefit could be demonstrated with additional or advanced TBA training though, overall neonatal death rate may be lower. The results may be encouraging but more evidence is needed to establish any concrete inference.

Specialized antenatal care clinics for women with a pregnancy at high risk of preterm birth (excluding multiple pregnancy) to improve maternal and infant outcomes

There is no clear evidence that specialized antenatal clinics improve maternal and infant outcomes. However, the included trials lacked sufficient statistical power to detect any possible difference between groups.

Surgical approach to hysterectomy for benign gynecological disease

This review assessed the effectiveness and safety of different surgical approaches to hysterectomy for women with benign gynecological conditions. There is insufficient evidence to make a strong recommendation regarding the optimal surgical management of benign gynecological conditions.

In vitro fertilization for unexplained subfertility

Unexplained subfertility is common, peaking at 26% in women above 35 years. Although in vitro fertilization (IVF) is widely accepted, it is invasive, expensive and associated with risks.

Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes

Repeat doses of corticosteroids should be offered to women at risk of preterm birth who remain undelivered seven or more days after initial course of corticosteroids to reduce the risk of respiratory distress syndrome and serious neonatal health problems.

Alternative versus standard packages of antenatal care for low-risk pregnancy

Reduced visits programmes of antenatal care are associated with an increase in perinatal mortality compared to standard care. Women are less satisfied with the reduced visits schedule and gaps between visits. Reduced visits schedule may be associated with lower costs.

Search WHO guidelines on sexual and reproductive health



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Methodological resources

Methodological and education resources for improved understanding of the concepts and discussions related to generation of best evidence


A set of training videos to help clinicians master details of manual or surgical procedures

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