New in RHL

Antidepressant treatment for postnatal depression

Postnatal depression (PND) affects more than 10% of postnatal women worldwide. Limited evidence from randomized trials found that selective serotonin reuptake inhibitors (SSRIs) are effective in addressing PND in terms of short-term response and remission. There was little evidence about effects on breastfeeding babies.

Immunotherapy for recurrent miscarriage

Attempts to induce maternal antibodies with paternal cells, third party donor leukocytes, trophoblast membranes or intravenous immunoglobulins have not proven effective in improving the chance of a live birth for women with recurrent miscarriages.

Closure versus non-closure of the peritoneum at caesarean section

Randomized trials have challenged the convention of suturing both visceral and parietal peritoneal layers during caesarean section. This review found that non-suturing of one or both layers reduces operation time and postoperative complications, with no apparent adverse effects.

Interventions to reduce haemorrhage during myomectomy for fibroids

Interventions found to reduce blood loss from myomectomy for leiomyomata (fibroids) of the uterus include: pericervical Foley catheter tourniquet, uterine artery ligation, various vasopressins and uterotonics, local haemostatics, and tranexamic acid.

Induction of labour in women at or beyond term

WHO recommends induction of labour in those women who are known with certainty to have reached 41 weeks gestation.

Methods of term labour induction for women with a previous cesarean section

There is currently insufficient evidence on the methods of term labour induction for women with a previous caesarean section. More research is required.

The use of uterotonics for the prevention of postpartum haemorrhage

WHO recommends the use of uterotonics for the prevention of postpartum haemorrhage during the third stage of labour.

Fetal assessment methods for improving neonatal and maternal outcomes in preterm prelabour rupture of membranes

There is insufficient data to support or refute the use of fetal assessment methods for improving neonatal and maternal outcomes in women with preterm prelabour rupture of membranes (PPROM), a condition that can increase the risk of respiratory distress, infection or brain haemorrhage in newborns.

Strategies of testing for syphilis during pregnancy

On-site syphilis screening strategy seems to show benefits regarding syphilis detection and treatment in pregnancy, reduction in incidence of congenital syphilis, and reduction in treatment delay when compared to conventional syphilis infection tests.

Postpartum misoprostol for preventing maternal mortality and morbidity

The use of postpartum misoprostol for prevention or treatment of postpartum haemorrhage is not associated with increased or decreased maternal mortality and serious morbidity (excluding hyperpyrexia).

Fetal fibronectin testing for reducing the risk of preterm birth

Current evidence is not sufficient to support the use of fetal fibronectin tests (FFT) for reducing the risk of preterm birth.



Health-care practice guidance from WHO and other institutions

Methodological resources

Methodological and education resources for improved understanding of the concepts and discussions related to generation of best evidence


A set of training videos to help clinicians master details of manual or surgical procedures

RHL on iPad

Available for iPad, the RHL app allows you to access the entire library offline