The use of calcium supplementation in pregnancy reduces the risk of pre-eclampsia, maternal death or severe morbidity and reduces the risk of preterm birth, especially in women with low dietary calcium intake or high risk of preeclampsia.
Antihypertensive therapy for mild to moderate hypertension during pregnancy reduces the risk of severe hypertensive episodes; however the clinical significance of this reduction for the mother and fetus is not clear. A significant effect on rates of pre-eclampsia has not been observed.
Giving prophylactic antibiotics to women with prelabour rupture of membranes (PROM) at or near term have shown no reduction in maternal infectious morbidity, early-onset neonatal sepsis, stillbirth, neonatal or perinatal mortality when compared to placebo or no treatment
Prophylactic administration of betamethasone to women undergoing elective caesarean section between 37 and 39 weeks of gestation seems to reduce the risk of admission to special and to intensive neonatal care units for respiratory distress.
There is insufficient evidence to support the routine use of antibiotics in the second and third trimesters to prevent infectious complications. However their use may reduce the risk of preterm delivery in selected patients, and may reduce the risk of postpartum infections.