Chlorhexidine vaginal washing during labour effectively reduces the bacterial load in the vagina, but has no effect on the risk of early-onset GBS illness. Further evaluation of its effectiveness is needed.
Postnatal depression (PND) affects more than 10% of postnatal women worldwide. Limited evidence from randomized trials found that selective serotonin reuptake inhibitors (SSRIs) are effective in addressing PND in terms of short-term response and remission. There was little evidence about effects on breastfeeding babies.
Attempts to induce maternal antibodies with paternal cells, third party donor leukocytes, trophoblast membranes or intravenous immunoglobulins have not proven effective in improving the chance of a live birth for women with recurrent miscarriages.
Randomized trials have challenged the convention of suturing both visceral and parietal peritoneal layers during caesarean section. This review found that non-suturing of one or both layers reduces operation time and postoperative complications, with no apparent adverse effects.
Interventions found to reduce blood loss from myomectomy for leiomyomata (fibroids) of the uterus include: pericervical Foley catheter tourniquet, uterine artery ligation, various vasopressins and uterotonics, local haemostatics, and tranexamic acid.
There is insufficient data to support or refute the use of fetal assessment methods for improving neonatal and maternal outcomes in women with preterm prelabour rupture of membranes (PPROM), a condition that can increase the risk of respiratory distress, infection or brain haemorrhage in newborns.
On-site syphilis screening strategy seems to show benefits regarding syphilis detection and treatment in pregnancy, reduction in incidence of congenital syphilis, and reduction in treatment delay when compared to conventional syphilis infection tests.