New in RHL

Prophylactic antibiotics for manual removal of retained placenta in vaginal birth

There are no randomized controlled trials evaluating the effectiveness of prophylactic antibiotics for manual removal of retained placenta in vaginal birth.

Antibiotic prophylaxis for third- and fourth-degree perineal tear during vaginal birth

The evidence to support the use of prophylactic antibiotics for third- and fourth- degree perineal tear after vaginal birth should be treated with caution.

Individual and contextual factors affecting antiretroviral treatment initiation, adherence, and retention for HIV-infected pregnant and postpartum women

Individual, interpersonal, community and structural factors can act as both enablers and barriers to the initiation, adherence and retention of antiretroviral treatment (ART) for HIV-infected pregnant women. Addressing these factors is crucial to implementing acceptable and effective ART programs that respond to women’s needs and perspectives.

Interventions for managing asthma in pregnancy

Evidence on the use of pharmacological and non-pharmacological interventions for the management of asthma during pregnancy is limited and further research is needed.

Ambroxol for women at risk of preterm birth for preventing neonatal respiratory distress syndrome

There is insufficient evidence to support or refute the role of ambroxol in preventing neonatal respiratory distress syndrome in women at risk of pre-term birth. Further information is required regarding the benefits and risks of treatment.

Minimally invasive surgical techniques versus open myomectomy for uterine fibroids

Laparoscopic myomectomy is associated with lower pain scores and lower risk of postoperative fever than open myomectomy, with no significant difference in other post-operative adverse events.

High-dose versus low-dose oxytocin infusion regimens for induction of labour at term

There is no clear evidence to support either high-dose or low-dose oxytocin infusion regimens, and further trials are needed.

Cervical stitch (cerclage) for preventing preterm birth in multiple pregnancy

This review found no evidence of benefit from cervical cerclage for preventing preterm birth in multiple pregnancy, and in women with cervical changes cerclage was associated with increased risks to the newborn.

Drugs for preventing malaria in pregnant women in endemic areas

Malaria chemoprevention for pregnant women in endemic areas has clinically important benefits for mothers and newborns

Skin preparation for preventing infection following caesarean section

Strategies to minimize post-caesarean section sepsis may contribute to reduction of maternal mortality and morbidity. This review found no significant differences between various types and methods of antiseptics, except very low quality evidence of reduced skin bacteria colony counts with chlorhexidine gluconate versus povidone-iodine. More research is needed.

Digital vaginal examination for routine assessment and identification of delay in active labour

Digital vaginal examination at intervals of four hours is recommended for routine assessment and identification of delay in active labour.



Health-care practice guidance from WHO and other institutions

Methodological resources

Methodological and education resources for improved understanding of the concepts and discussions related to generation of best evidence


A set of training videos to help clinicians master details of manual or surgical procedures

RHL on iPad

Available for iPad, the RHL app allows you to access the entire library offline