One major challenge of national medicines policies is the ability to ensure that their implementation plans include the uninterrupted supply of essential medicines that are safe and efficacious, physically and financially accessible and use rationally. Unfortunately, in some countries especially in sub-Saharan Africa, the medicines supply systems are often unreliable and therefore do not guarantee regular supply of these essential medicines. Since medicines and medical supplies in general, form the backbone of all health systems worldwide, there is always the need to ensure their quality and regular availability in the right quantities at affordable prices. This assessment was undertaken to determine the current status of medicines supply management system in the public sector in Ghana.