Canada. Health Canada has received four reports of suspected ibuprofen-associated Stevens-Johnson syndrome between 1 January 1973 and 21 February 2005, according to the Canadian Adverse Reaction Newsletter. All four reports were received after April 2001 and involved patients aged 13.34 years who had received ibuprofen 200.1200 mg/day. The time to reaction onset ranged from the day of administration to about 15 days after ibuprofen initiation, and carbamazepine was also identified as a suspect drug in one report. At the time of the reports, the outcome was unknown for one patient and three of the patients had not recovered.

Reference:

Canadian Adverse Reaction Newsletter July 2005, No. 3.