The Quality of Antimalarials - A Study in Selected African Countries - EDM Research Series No. 030
(2003; 67 pages) Voir le document au format PDF
Table des matières
Afficher le documentAuthors
Afficher le documentCountry Research Team Leaders
Afficher le documentLaboratory Support
Afficher le documentAcknowledgements
Afficher le documentAcronyms
Afficher le documentExecutive summary
Afficher le document1. Background
Fermer ce répertoire2. Methodology
Ouvrir ce répertoire et afficher son contenu2.1 Analytical methods
Fermer ce répertoire2.2 Dissolution testing
Afficher le document2.2.1 Dissolution method for chloroquine tablets
Afficher le document2.2.2 Dissolution method for sulphadoxine/pyrimethamine tablets
Afficher le document3. Results
Ouvrir ce répertoire et afficher son contenu4. Discussion
Ouvrir ce répertoire et afficher son contenu5. Conclusions and recommendations
Afficher le documentReferences
Ouvrir ce répertoire et afficher son contenuTables
Ouvrir ce répertoire et afficher son contenuAnnexes
Afficher le documentOther documents in the EDM Research Series
Afficher le documentEDM Research Series No. 30
 

2.2.1 Dissolution method for chloroquine tablets

The dissolution parameters for chloroquine tablets (USP 24) were as follows:

Apparatus:

Apparatus 2 of the USP

Stir rate:

100 rpm

Dissolution medium:

900 ml water

Q-value:

75%

Time:

45 minutes

Sample volume:

5 ml

Six tabletsa were introduced into the dissolution vessels. Samples (5ml) of the dissolution media in the different vessels were withdrawn after 45 minutes and after further dilution, analysed for chloroquine content according to the prescribed UV spectrophotometric method in the USP for the dissolution testing of chloroquine phosphate tablets. The amount of chloroquine dissolved after 45 minutes is expressed as a percentage of the label claim.

a Where fewer than six tablets were available, at least three were analysed for dissolution in order to indicate trends

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