The Quality of Antimalarials - A Study in Selected African Countries - EDM Research Series No. 030
(2003; 67 pages) Voir le document au format PDF
Table des matières
Afficher le documentAuthors
Afficher le documentCountry Research Team Leaders
Afficher le documentLaboratory Support
Afficher le documentAcknowledgements
Afficher le documentAcronyms
Afficher le documentExecutive summary
Afficher le document1. Background
Fermer ce répertoire2. Methodology
Fermer ce répertoire2.1 Analytical methods
Afficher le document2.1.1 Method for the assay of chloroquine syrup
Afficher le document2.1.2 Method for the assay of chloroquine tablets
Afficher le document2.1.3 Method for the assay of sulphadoxine/pyrimethamine tablets
Ouvrir ce répertoire et afficher son contenu2.2 Dissolution testing
Afficher le document3. Results
Ouvrir ce répertoire et afficher son contenu4. Discussion
Ouvrir ce répertoire et afficher son contenu5. Conclusions and recommendations
Afficher le documentReferences
Ouvrir ce répertoire et afficher son contenuTables
Ouvrir ce répertoire et afficher son contenuAnnexes
Afficher le documentOther documents in the EDM Research Series
Afficher le documentEDM Research Series No. 30
 

2.1.2 Method for the assay of chloroquine tablets

The content of chloroquine was determined by UV-spectrophotometry in accordance with an adapted method for chloroquine phosphate tablets of the USP 24. The method consists of recording the UV absorbance of the sample at a wavelength of 343 nm and comparing it to the absorbance of a reference standard in a concentration range representing a 100% label claim at the same wavelength.

The method was adapted in such a way that it was possible to determine the quantity of the different salt forms of chloroquine in the tablets, where applicable. As all USP methods are specific for the analyte, the method was only validated in terms of precision. Interference from excipients was validated by superimposing the UV spectra of the sample and standard.

No interference from excipients was noted, and the precision of the method was %RSD < 2.

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