Singapore - The Drug Monitoring Unit has received 3 reports of seizures with bupropion/amfebutamone (Zyban®) in recipients who had not consumed alcohol and had no history of seizure disorders. The men, aged between 37 and 41 years, were hospitalized with seizures 5 - 10 days after starting treatment with bupropion 150 mg twice daily. They all subsequently recovered and did not experience another seizure. The risk of seizures in patients with factors that may predispose them to this condition is emphasised. Other adverse events reported in association with bupropion in Singapore include insomnia, facial oedema, chest pain and vomiting.

Reference: Adverse Drug Reaction News, 3: 4 (2001).