Stability of Oral Oxytocics in Tropical Climates - Results of Simulation Studies on Oral Ergometrine, Oral Methylergometrine, Buccal Oxytocin and Buccal Desamino-Oxytocin - EDM Research Series No. 012
(1994; 52 pages) Voir le document au format PDF
Table des matières
Afficher le documentAbbreviations
Afficher le documentSummary
Ouvrir ce répertoire et afficher son contenuIntroduction
Ouvrir ce répertoire et afficher son contenuMaterials and methods
Ouvrir ce répertoire et afficher son contenuResults
Ouvrir ce répertoire et afficher son contenuDiscussion
Afficher le documentConclusions and recommendations
Afficher le documentReferences
Fermer ce répertoireAnnexes
Afficher le documentAnnex 1: Ergometrine 0.2 mg tablets
Afficher le documentAnnex 2: Methylergometrine 0.125 mg tablets
Afficher le documentAnnex 3: Buccal oxytocin 200 IU
Afficher le documentAnnex 4: Buccal desamino-oxytocin, 50 IU
Afficher le documentAnnex 5: Summary of results
Afficher le documentAnnex 6: Figures 1 to 7
 

Annex 4: Buccal desamino-oxytocin, 50 IU

Stated amount: 50 IU (= 100%)

test I: D6/83

time (weeks)

mean conc/tablet (HPLC)

% HPLC

SD

SD/mean x100% CV%

n

0

49.887

99.7

5.272

10.6

20

3

49.050

98.1

0.901

1.8

3

7

49.671

99.3

2.449

4.9

8

14

48.968

97.9

1.117

2.3

4

23

44.725

89.5

0.746

1.7

4

33

27.55

55.1

2.623

9.5

9

45

29.5

59.0

1.103

3.7

6

53

25.667

51.3

0.945

3.7

3

test II: D20/75

time (weeks)

mean conc/tablet (HPLC)

% HPLC

SD

SD/mean x100% CV%

n

0

49.887

99.7

5.272

10.6

20

3

45.253

90.5

6.474

14.3

3

14

47.765

95.5

3.638

7.6

4

23

46.9

93.8

1.952

4.2

4

33

7.020

14.0

4.530

64.5

5

45

1.625

3.2

0.417

25.6

4

53

0.563

1.1

0.302

53.6

15

test III: D30/45

time (weeks)

mean conc/tablet (HPLC)

% HPLC

SD

SD/mean x100% CV%

n

0

49.887

99.7

5.272

10.6

20

3

42.007

84.0

2.506

6.0

3

7

43.088

86.2

1.915

4.4

4

14

44.357

88.7

4.636

10.5

3

23

44.29

88.6

3.741

8.4

4

33

22.958

45.9

2.188

9.5

6

45

21.918

43.8

1.342

6.1

11

72

19.421

38.8

1.321

6.8

19

Buccal desamino-oxytocin, 50 IU

test IV: D30/75

time (weeks)

mean conc/tablet (HPLC)

% HPLC

SD

SD/mean x100% CV%

n

0

49.887

99.7

5.272

10.6

20

3

44.90

89.8

6.42

14

3

7

46.538

93.1

3.708

7.9

4

14

37.578

75.2

2.820

7.5

4

23

35.590

71.2

8.334

23.4

4

33

18.608

37.2

1.346

7.2

6

45

19.008

38.0

0.797

4.2

6

53

18.163

36.3

1.040

5.7

16

test V: D40/25

time (weeks)

mean conc/tablet (HPLC)

% HPLC

SD

SD/mean x100% CV%

n

0

49.887

99.7

5.272

10.6

20

3

47.990

96.0

5.141

10.7

3

7

49.963

99.9

0.883

1.8

4

14

36.405

72.8

8.302

22.8

4

23

39.373

78.7

1.783

4.5

4

33

30.925

61.9

2.513

8.1

6

45

31.392

62.8

2.207

7.0

6

53

30.454

60.9

1.582

5.2

12

72

30.348

60.7

1.793

5.9

9

test VI: D40/75

time (weeks)

mean conc/tablet (HPLC)

% HPLC

SD

SD/mean x100% CV%

n

0

49.887

99.7

5.272

10.6

20

3

41.000

82.0

8.516

20.7

3

7

43.250

86.5

2.412

5.6

4

14

33.608

67.2

3.384

10.1

4

23

29.615

59.2

2.282

7.7

4

33

10.500

21

0.711

6.8

6

45

8.100

16.2

0.304

3.8

3

53

6.887

13.8

0.529

7.7

15

Buccal desamino-oxytocin, 50 IU

test VII: L20/30

time (weeks)

mean conc/tablet (HPLC)

% HPLC

SD

SD/mean x100% CV%

n

0

49.887

99.7

5.272

10.6

20

3

48.707

97.4

2.394

4.9

3

7

47.7

95.4

1.863

3.9

4

14

39.21

78.4

1.521

3.9

4

23

41.15

82.3

2.248

5.5

4

33

31.367

62.7

2.513

8.0

6

45

29.387

58.8

1.801

6.1

12

53

27.786

55.6

2.098

7.6

18

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