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Stability of Oral Oxytocics in Tropical Climates - Results of Simulation Studies on Oral Ergometrine, Oral Methylergometrine, Buccal Oxytocin and Buccal Desamino-Oxytocin - EDM Research Series No. 012
(1994; 52 pages) Voir le document au format PDF
Table des matières
Afficher le documentAbbreviations
Afficher le documentSummary
Ouvrir ce répertoire et afficher son contenuIntroduction
Ouvrir ce répertoire et afficher son contenuMaterials and methods
Ouvrir ce répertoire et afficher son contenuResults
Ouvrir ce répertoire et afficher son contenuDiscussion
Afficher le documentConclusions and recommendations
Afficher le documentReferences
Ouvrir ce répertoire et afficher son contenuAnnexes

Conclusions and recommendations

Oral ergometrine (E) and methylergometrine (ME) tablets and buccal oxytocin (OT) and desamino-oxytocin (DOT) tablets are not stable under simulated tropical conditions, and are therefore not suitable for use in the prevention of PPH in tropical climates. It is unlikely that the serious instability of E and ME under simulated tropical conditions can be improved by a different formulation. Moreover, pharmacokinetic data on buccal OT and DOT seem far from reliable (40). Pharmacokinetic studies on buccal OT and DOT (33-37) and the data obtained in this study on their stability do not justify efforts to improve their stability.

Injectable oxytocin therefore remains the best choice of oxytocic for prophylactic use in the prevention of PPH, although its intramuscular route of administration is not ideal. Investigation of the possibility of formulating and manufacturing a stable non-injectable alternative to oxytocin is recommended.


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