Stability of Oral Oxytocics in Tropical Climates - Results of Simulation Studies on Oral Ergometrine, Oral Methylergometrine, Buccal Oxytocin and Buccal Desamino-Oxytocin - EDM Research Series No. 012
(1994; 52 pages) Voir le document au format PDF
Table des matières
Afficher le documentAbbreviations
Afficher le documentSummary
Ouvrir ce répertoire et afficher son contenuIntroduction
Ouvrir ce répertoire et afficher son contenuMaterials and methods
Fermer ce répertoireResults
Afficher le documentErgometrine (E)
Afficher le documentMethylergometrine (ME)
Afficher le documentOxytocin (OT)
Afficher le documentDesamino-oxytocin (DOT)
Ouvrir ce répertoire et afficher son contenuDiscussion
Afficher le documentConclusions and recommendations
Afficher le documentReferences
Ouvrir ce répertoire et afficher son contenuAnnexes


The results of the simulation study are given in Annexes 1-6. For each preparation the mean analytical results per condition are reported, with the standard deviation, coefficients of variation and the number examined.

At t=0, the initial amount of 20 tablets of each brand contained between 90-110% of the stated amount of the active ingredient and thus met BP requirements. The level of active ingredient, expressed as a percentage of the stated amount, is shown over time for each preparation and for all conditions (Annex 5). The main findings are illustrated in Annex 6, showing the level of active ingredient over time in the least (test I) and most harmful conditions (test VI) and after exposure to light. Results of the simulation studies of E and ME are given in Figures 1 to 3 and the results of OT and DOT in Figures 4-8.

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